Sameed Ahmed,Anita T Layton
Sameed Ahmed
In the past decades, substantial effort has been devoted to the development of computational models of the cardiovascular system. Some of these models simulate blood pressure regulation in humans and include components of the circulatory, r...
Urethral dysfunction in a rat model of chemically induced prostatic inflammation: potential involvement of the MRP5 pump [0.03%]
化学诱导的前列腺炎大鼠模型尿道功能障碍：MRP5泵的潜在作用
Eduardo C Alexandre,Nailong Cao,Shinsuke Mizoguchi et al.
Eduardo C Alexandre et al.
Prostate inflammation (PI) is a clinical condition associated with infection and/or inflammation of the prostate. It is a common disease frequently associated to lower urinary tract (LUT) symptoms. The urethra is an understudied structure i...
Ablation of Gsa impairs renal tubule proliferation after injury via CDK2/cyclin E [0.03%]
Gsa敲除通过CDK2/cyclin E抑制肾小管损伤后的增殖
Lele Liu,Yuanjun Deng,Yang Cai et al.
Lele Liu et al.
Acute kidney injury has a high global morbidity associated with an increased risk of death and chronic kidney disease. Renal tubular epithelial cell regeneration following injury may be a decisive factor in renal repair or the progression o...
Soluble Fas affects erythropoiesis in vitro and acts as a potential predictor of erythropoiesis-stimulating agent therapy in patients with chronic kidney disease [0.03%]
可溶性Fas影响体外红系生成并可能作为慢性肾脏病患者促红细胞生成素治疗的预测指标
Daniela Mendes Chiloff,Danilo Candido de Almeida,Maria A Dalboni et al.
Daniela Mendes Chiloff et al.
Serum soluble Fas (sFas) levels are associated with erythropoietin (Epo) hyporesponsiveness in patients with chronic kidney disease (CKD). Whether sFas could predict the need for erythropoiesis-stimulating agent (ESA) usage and its influenc...
Lizath M Aguiniga,Timothy J Searl,Afrida Rahman-Enyart et al.
Lizath M Aguiniga et al.
Corticotropin-releasing factor (CRF) regulates diverse physiological functions, including bladder control. We recently reported that Crf expression is under genetic control of Aoah, the locus encoding acyloxyacyl hydrolase (AOAH), suggestin...
miR-214 represses mitofusin-2 to promote renal tubular apoptosis in ischemic acute kidney injury [0.03%]
缺血性急性肾损伤中miR-214通过抑制线粒体融合蛋白2促进肾小管上皮细胞凋亡
Yu Yan,Zhengwei Ma,Jiefu Zhu et al.
Yu Yan et al.
Disruption of mitochondrial dynamics is an important pathogenic event in both acute and chronic kidney diseases, but the underlying mechanism remains poorly understood. Here, we report the regulation of mitofusin-2 (Mfn2; a key mitochondria...
Sophie Møller,Jens Christian Brings Jacobsen,Thomas H Braunstein et al.
Sophie Møller et al.
Renal autoregulation is mediated by the myogenic response and tubuloglomerular feedback (TGF) working in concert to maintain renal blood flow and glomerular filtration rate despite fluctuations in renal perfusion pressure. Intercellular com...
Inhibitor of myogenic differentiation family isoform a, a new positive regulator of fibronectin production by glomerular mesangial cells [0.03%]
肌细胞分化抑制因子家族异构体a是肾小球系膜细胞产生纤连蛋白的新阳性调节因子
Parisa Yazdizadeh Shotorbani,Sarika Chaudhari,Yu Tao et al.
Parisa Yazdizadeh Shotorbani et al.
Overproduction of extracellular matrix proteins, including fibronectin by mesangial cells (MCs), contributes to diabetic nephropathy. Inhibitor of myogenic differentiation family isoform a (I-mfa) is a multifunctional cytosolic protein func...
Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho [0.03%]
贝利CHEK1/Bcl-2复合物依赖的自噬活性调节缺血再灌注损伤引起的肾病并介导希腊女神克洛托的肾脏保护作用
Peng Li,Mingjun Shi,Jenny Maique et al.
Peng Li et al.
Klotho- and beclin 1-driven autophagy extends life. We examined the role of beclin 1 in modifying acute kidney injury (AKI) and whether beclin 1 mediates Klotho's known renoprotective action in AKI. AKI was induced by ischemia-reperfusion i...
Elena Tutunea-Fatan,Jasper C Lee,Bradley M Denker et al.
Elena Tutunea-Fatan et al.
Gα12 and Gα13 are ubiquitous members of the heterotrimeric guanine nucleotide-binding protein (G protein) family that play central and integrative roles in the regulation of signal transduction cascades within various cell types in the ki...