Evolution, biomechanics, and neurobiology converge to explain selective finger motor control [0.03%]
进化、生物力学和神经生物学汇聚以解释选择性手指运动控制
Jing Xu,Firas Mawase,Marc H Schieber
Jing Xu
Humans use their fingers to perform a variety of tasks, from simple grasping to manipulating objects, to typing and playing musical instruments, a variety wider than any other species. The more sophisticated the task, the more it involves i...
Navigating the multifaceted intricacies of the Na+-Cl- cotransporter, a highly regulated key effector in the control of hydromineral homeostasis [0.03%]
Na +-Cl -协同转运蛋白的多方面复杂性，是水盐稳态控制中高度调控的关键效应因子导航
A V Rioux,T R Nsimba-Batomene,S Slimani et al.
A V Rioux et al.
The Na+-Cl- cotransporter (NCC; SLC12A3) is a highly regulated integral membrane protein that is known to exist as three splice variants in primates. Its primary role in the kidney is to mediate the cosymport of Na+ and Cl- across the apica...
Emily Hamburg-Shields,Sam Mesiano
Emily Hamburg-Shields
Parturition is a complex physiological process that must occur in a reliable manner and at an appropriate gestation stage to ensure a healthy newborn and mother. To this end, hormones that affect the function of the gravid uterus, especiall...
Joseph L Wilkerson,Sean M Tatum,William L Holland et al.
Joseph L Wilkerson et al.
Ceramides are signals of fatty acid excess that accumulate when a cell's energetic needs have been met and its nutrient storage has reached capacity. As these sphingolipids accrue, they alter the metabolism and survival of cells throughout ...
Sarina Kajani,Rhianna C Laker,Ekaterina Ratkova et al.
Sarina Kajani et al.
Glucagon's ability to promote hepatic glucose production has been known for over a century, with initial observations touting this hormone as a diabetogenic agent. However, glucagon receptor agonism [when balanced with an incretin, includin...
Proteomics of the heart [0.03%]
心脏的蛋白质组学研究
Oleg A Karpov,Aleksandr Stotland,Koen Raedschelders et al.
Oleg A Karpov et al.
Mass spectrometry-based proteomics is a sophisticated identification tool specializing in portraying protein dynamics at a molecular level. Proteomics provides biologists with a snapshot of context-dependent protein and proteoform expressio...
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases [0.03%]
眼前房技术及其解剖学，光学和免疫学基础
Shao-Nian Yang,Yue Shi,Per-Olof Berggren
Shao-Nian Yang
The anterior chamber of the eye (ACE) is distinct in its anatomy, optics, and immunology. This guarantees that the eye perceives visual information in the context of physiology even when encountering adverse incidents like inflammation. In ...
Rafal Butowt,Christopher S von Bartheld
Rafal Butowt
Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation [0.03%]
心脏电生理学和心律失常的计算建模：迈向临床转化
Natalia A Trayanova,Aurore Lyon,Julie Shade et al.
Natalia A Trayanova et al.
The complexity of cardiac electrophysiology, involving dynamic changes in numerous components across multiple spatial (from ion channel to organ) and temporal (from milliseconds to days) scales, makes an intuitive or empirical analysis of c...
The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract [0.03%]
微生物组：呼吸道免疫稳态和炎症的重要参与者
Olaf Perdijk,Rossana Azzoni,Benjamin J Marsland
Olaf Perdijk
The last decade of microbiome research has highlighted its fundamental role in systemic immune and metabolic homeostasis. The microbiome plays a prominent role during gestation and into early life, when maternal lifestyle factors shape immu...