Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives [0.03%]
脂质通过离子通道和受体调节塑造脑功能：生理机制与临床意义
Salvatore Incontro,Maria Laura Musella,Malika Sammari et al.
Salvatore Incontro et al.
Lipids represent the most abundant molecular type in the brain with a fat content of approximately 60% of the dry brain weight in humans. Despite this fact, little attention has been paid to circumscribe the dynamic role of lipids in brain ...
Eukaryotic cell size regulation and its implications for cellular function and dysfunction [0.03%]
真核细胞大小调控及其对细胞功能与功能障碍的影响
Yagya Chadha,Arohi Khurana,Kurt M Schmoller
Yagya Chadha
Depending on cell type, environmental inputs, and disease, the cells in the human body can have widely different sizes. In recent years, it became clear that cell size is a major regulator of cell function. However, we are only beginning to...
Understanding Coenzyme Q [0.03%]
辅酶Q的认识
Ying Wang,Noah Lilienfeldt,Siegfried Hekimi
Ying Wang
Coenzyme Q (CoQ), also known as ubiquinone, comprises a benzoquinone head group and a long isoprenoid sidechain. It is thus extremely hydrophobic and resides in membranes. It is best known for its complex function as an electron transporter...
A versatile delivery vehicle for cellular oxygen and fuels, or metabolic sensor? - A review and perspective on the functions of myoglobin [0.03%]
细胞供氧和供燃料的多功能递送载体，还是代谢传感器？——肌红蛋白功能综述与展望
Kiran Kumar Adepu,Andriy Anishkin,Sean H Adams et al.
Kiran Kumar Adepu et al.
A canonical view of the primary physiological function of myoglobin (Mb) is that it is an oxygen (O2) storage protein supporting mitochondrial oxidative phosphorylation, especially as the tissue O2 partial pressure (pO2) drops and Mb offloa...
Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion [0.03%]
神经元葡萄糖感应机制和电路在胰岛素及胰高血糖素分泌控制中的作用
Bernard Thorens
Bernard Thorens
Glucose homeostasis is mainly under the control of the pancreatic islet hormones insulin and glucagon, which, respectively, stimulate glucose uptake and utilization by liver, fat, and muscle and glucose production by the liver. The balance ...
Physiological basis for xenotransplantation from genetically modified pigs to humans [0.03%]
转基因猪到人类移植的生理基础
Leigh Peterson,Magdi H Yacoub,David Ayares et al.
Leigh Peterson et al.
The collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning that are now being harnessed to enhance the suitabilit...
Raffael Kalisch,Scott J Russo,Marianne B Müller
Raffael Kalisch
Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts to unravel the factors and mechanism...
Meiqin Hu,Xinghua Feng,Qiang Liu et al.
Meiqin Hu et al.
The endomembrane system consists of organellar membranes in the biosynthetic pathway [endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the degradative pathway (early endosomes, macropinosomes, phagoso...
Best practices for data management and sharing in experimental biomedical research [0.03%]
实验生物医学研究中数据管理和共享的最佳实践
Teresa Cunha-Oliveira,John P A Ioannidis,Paulo J Oliveira
Teresa Cunha-Oliveira
Effective data management is crucial for scientific integrity and reproducibility, a cornerstone of scientific progress. Well-organized and well-documented data enable validation and building on results. Data management encompasses activiti...
Mechanisms of myosin II force generation. Insights from novel experimental techniques and approaches [0.03%]
II型肌球蛋白力量产生的机制。来自新型实验技术方法的启示
Dilson E Rassier,Alf Månsson
Dilson E Rassier
Myosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range of cell functions relying on the development of force and m...