Degenerate neuronal and circuit mechanisms important for generating rhythmic motor patterns [0.03%]
退化神经元与产生节律性运动模式的重要电路机制
Ronald L Calabrese,Eve Marder
Ronald L Calabrese
In 1996, we published a review article (Marder E, Calabrese RL. Physiol Rev 76: 687-717, 1996) describing the state of knowledge about the structure and function of the central pattern-generating circuits important for producing rhythmic be...
Juan Sastre,Salvador Pérez,Luis Sabater et al.
Juan Sastre et al.
This review addresses oxidative stress and redox signaling in the pancreas under physiological conditions as well as in acute pancreatitis, chronic pancreatitis, pancreatic cancer, and diabetes. Physiological redox homeodynamics is maintain...
The liver as a central "hub" of the immune system: pathophysiological implications [0.03%]
肝脏作为免疫系统的中央"管理中心":病理生理意义
Vincenzo Ronca,Alessio Gerussi,Paul Collins et al.
Vincenzo Ronca et al.
The purpose of this review is to describe the immune function of the liver, guiding the reader from the homeostatic tolerogenic status to the aberrant activation demonstrated in chronic liver disease. An extensive description of the pathway...
Mammalian copper homeostasis: physiological roles and molecular mechanisms [0.03%]
哺乳动物铜稳态：生理作用与分子机制
Svetlana Lutsenko,Shubhrajit Roy,Peter Tsvetkov
Svetlana Lutsenko
In the past decade, evidence for the numerous roles of copper (Cu) in mammalian physiology has grown exponentially. The discoveries of Cu involvement in cell signaling, autophagy, cell motility, differentiation, and regulated cell death (cu...
Harris S Kaplan,Patricia M Horvath,Mohammed Mostafizur Rahman et al.
Harris S Kaplan et al.
Parenting behavior comprises a variety of adult-infant and adult-adult interactions across multiple timescales. The state transition from nonparent to parent requires an extensive reorganization of individual priorities and physiology and i...
David G Benditt,Artur Fedorowski,Richard Sutton et al.
David G Benditt et al.
Syncope is a symptom in which transient loss of consciousness occurs as a consequence of a self-limited, spontaneously terminating period of cerebral hypoperfusion. Many circulatory disturbances (e.g. brady- or tachyarrhythmias, reflex card...
The calculating brain [0.03%]
运算的大脑
Andreas Nieder
Andreas Nieder
The human brain possesses neural networks and mechanisms enabling the representation of numbers, basic arithmetic operations, and mathematical reasoning. Without the ability to represent numerical quantity and perform calculations, our scie...
Nanodomain cAMP signalling in cardiac pathophysiology: potential for developing targeted therapeutic interventions [0.03%]
纳米结构环核苷酸信使cAMP在心脏疾病病理生理学中的作用及发展靶向治疗的潜能
Manuela Zaccolo,Duangnapa Kovanich
Manuela Zaccolo
3', 5'-cyclic adenosine monophosphate (cAMP) mediates the effects of sympathetic stimulation on the rate and strength of cardiac contraction. Beyond this pivotal role, in cardiac myocytes cAMP also orchestrates a diverse array of reactions ...
Lung antimicrobial proteins and peptides: from host defense to therapeutic strategies [0.03%]
肺抗微生物蛋白质和多肽：从宿主防御到治疗策略
Yuanpu Peter Di,Jenna Marie Kuhn,Maria Luisa Mangoni
Yuanpu Peter Di
Representing severe morbidity and mortality globally, respiratory infections associated with chronic respiratory diseases, including complicated pneumonia, asthma, interstitial lung disease, and chronic obstructive pulmonary disease, are a ...
Modulating vertebrate physiology by genomic fine-tuning of GPCR functions [0.03%]
通过基因组精细调节GPCR功能来调控脊椎动物生理学
Torsten Schöneberg
Torsten Schöneberg
G protein-coupled receptors (GPCRs) play a crucial role as membrane receptors, facilitating the communication of eukaryotic species with their environment and regulating cellular and organ interactions. Consequently, GPCRs hold immense pote...