Molecular background of leak K+ currents: two-pore domain potassium channels [0.03%]
漏钾电流的分子背景：两孔结构钾通道
Péter Enyedi,Gábor Czirják
Péter Enyedi
Two-pore domain K(+) (K(2P)) channels give rise to leak (also called background) K(+) currents. The well-known role of background K(+) currents is to stabilize the negative resting membrane potential and counterbalance depolarization. Howev...
Sympathetic nervous system overactivity and its role in the development of cardiovascular disease [0.03%]
交感神经系统的过度活跃及其在心血管疾病发展中的作用
Simon C Malpas
Simon C Malpas
This review examines how the sympathetic nervous system plays a major role in the regulation of cardiovascular function over multiple time scales. This is achieved through differential regulation of sympathetic outflow to a variety of organ...
Nadine Bakkar,Denis C Guttridge
Nadine Bakkar
NF-kappaB is a ubiquitiously expressed transcription factor that plays vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. Activation of NF-kappaB is controlled by an IkappaB k...
Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process [0.03%]
阿尔茨海默病中的蛋白酶与蛋白质水解：对该疾病过程的多因素观点
Bart De Strooper
Bart De Strooper
Alzheimer disease is characterized by the accumulation of abnormally folded protein fragments, i.e., amyloid beta peptide (Abeta) and tau that precipitate in amyloid plaques and neuronal tangles, respectively. In this review we discuss the ...
Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear [0.03%]
关于获得、表达和消退的杏仁基质塑性突触网络研究
Hans-Christian Pape,Denis Pare
Hans-Christian Pape
The last 10 years have witnessed a surge of interest for the mechanisms underlying the acquisition and extinction of classically conditioned fear responses. In part, this results from the realization that abnormalities in fear learning mech...
Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease [0.03%]
膜脂肪酸转运蛋白：脂代谢的调节者及其在代谢性疾病中的意义
Jan F C Glatz,Joost J F P Luiken,Arend Bonen
Jan F C Glatz
Long-chain fatty acids and lipids serve a wide variety of functions in mammalian homeostasis, particularly in the formation and dynamic properties of biological membranes and as fuels for energy production in tissues such as heart and skele...
Inwardly rectifying potassium channels: their structure, function, and physiological roles [0.03%]
内向整流钾通道的结构、功能及生理作用
Hiroshi Hibino,Atsushi Inanobe,Kazuharu Furutani et al.
Hiroshi Hibino et al.
Inwardly rectifying K(+) (Kir) channels allow K(+) to move more easily into rather than out of the cell. They have diverse physiological functions depending on their type and their location. There are seven Kir channel subfamilies that can ...
Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides [0.03%]
磷脂酰肌醇对肌动蛋白细胞骨架-质膜相互作用的调控
Juha Saarikangas,Hongxia Zhao,Pekka Lappalainen
Juha Saarikangas
The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous dynamic interplay that is responsible for many essential aspects of cell physiology. Polymerization of actin filaments against cellular membranes provides...
Gary D Lopaschuk,John R Ussher,Clifford D L Folmes et al.
Gary D Lopaschuk et al.
There is a constant high demand for energy to sustain the continuous contractile activity of the heart, which is met primarily by the beta-oxidation of long-chain fatty acids. The control of fatty acid beta-oxidation is complex and is aimed...
Richard T Mathias,Thomas W White,Xiaohua Gong
Richard T Mathias
The cells of most mammalian organs are connected by groups of cell-to-cell channels called gap junctions. Gap junction channels are made from the connexin (Cx) family of proteins. There are at least 20 isoforms of connexins, and most tissue...