Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale [0.03%]
-map激酶在心脏中的信号转导：天使与恶魔的心碎故事
Beth A Rose,Thomas Force,Yibin Wang
Beth A Rose
Among the myriad of intracellular signaling networks that govern the cardiac development and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that have been the focus of extensive investigations in the past deca...
Zafir Buraei,Jian Yang
Zafir Buraei
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle contraction, neuronal communication, hormone release, cell division, and gene transcription. Major entryways for Ca(2+) in excitable cells are high-volta...
Henrike Berkefeld,Bernd Fakler,Uwe Schulte
Henrike Berkefeld
Molecular research on ion channels has demonstrated that many of these integral membrane proteins associate with partner proteins, often versatile in their function, or even assemble into stable macromolecular complexes that ensure specific...
Brinda Ravikumar,Sovan Sarkar,Janet E Davies et al.
Brinda Ravikumar et al.
(Macro)autophagy is a bulk degradation process that mediates the clearance of long-lived proteins and organelles. Autophagy is initiated by double-membraned structures, which engulf portions of cytoplasm. The resulting autophagosomes ultima...
Beth B McConnell,Vincent W Yang
Beth B McConnell
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological processes that include proliferation, differentiation, growth, development, survival, and responses to external stress. Seventeen mammalian KLFs hav...
Yuansheng Gao,J Usha Raj
Yuansheng Gao
During the development of the pulmonary vasculature in the fetus, many structural and functional changes occur to prepare the lung for the transition to air breathing. The development of the pulmonary circulation is genetically controlled b...
Fluid transport across leaky epithelia: central role of the tight junction and supporting role of aquaporins [0.03%]
渗漏上皮的液体转运：紧密连接的中心作用及水通道蛋白的辅助作用
Jorge Fischbarg
Jorge Fischbarg
The mechanism of epithelial fluid transport remains unsolved, which is partly due to inherent experimental difficulties. However, a preparation with which our laboratory works, the corneal endothelium, is a simple leaky secretory epithelium...
Neurophysiological and computational principles of cortical rhythms in cognition [0.03%]
认知中的皮层节律的神经生理和计算原理
Xiao-Jing Wang
Xiao-Jing Wang
Synchronous rhythms represent a core mechanism for sculpting temporal coordination of neural activity in the brain-wide network. This review focuses on oscillations in the cerebral cortex that occur during cognition, in alert behaving condi...
Harmeet Malhi,Maria Eugenia Guicciardi,Gregory J Gores
Harmeet Malhi
The hepatocyte is especially vulnerable to injury due to its central role in xenobiotic metabolism including drugs and alcohol, participation in lipid and fatty acid metabolism, its unique role in the enterohepatic circulation of bile acids...
Fluorescent proteins and their applications in imaging living cells and tissues [0.03%]
荧光蛋白及其在活体细胞和组织成像中的应用
Dmitriy M Chudakov,Mikhail V Matz,Sergey Lukyanov et al.
Dmitriy M Chudakov et al.
Green fluorescent protein (GFP) from the jellyfish Aequorea victoria and its homologs from diverse marine animals are widely used as universal genetically encoded fluorescent labels. Many laboratories have focused their efforts on identific...