Gregory J Morton,Michael W Schwartz
Gregory J Morton
The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying ...
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives [0.03%]
紊乱流场对血管内皮细胞的影响：病理生理基础与临床意义
Jeng-Jiann Chiu,Shu Chien
Jeng-Jiann Chiu
Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC functions and vascular biology/pathobiology in health and disease. The flow patterns and hemodynamic forces are not uniform in the vascular system. In str...
Pathophysiological mechanisms of atrial fibrillation: a translational appraisal [0.03%]
心房颤动的病理生理机制——转化医学评估
Ulrich Schotten,Sander Verheule,Paulus Kirchhof et al.
Ulrich Schotten et al.
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different pathophysiological processes in the atria. Some aspects of the morphological and electrophysiological alterations promoting AF have been studied ex...
Dianhua Jiang,Jiurong Liang,Paul W Noble
Dianhua Jiang
Accumulation and turnover of extracellular matrix components are the hallmarks of tissue injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety of immune cells at the injury site. Hyaluronan binds to a nu...
James A McCormick,David H Ellison
James A McCormick
WNKs are serine/threonine kinases that comprise a unique branch of the kinome. They are so-named owing to the unusual placement of an essential catalytic lysine. WNKs have now been identified in diverse organisms. In humans and other mammal...
Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer [0.03%]
zonulin与肠屏障功能的调节：通向炎症、自身免疫和癌症的生物学之门
Alessio Fasano
Alessio Fasano
The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and to electrolytes and water homeostasis. A more attentive analysis of the anatomic and functi...
Alex H Hutagalung,Peter J Novick
Alex H Hutagalung
Intracellular membrane traffic defines a complex network of pathways that connects many of the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by its own set of factors, they all contain Rab GTPases that ser...
Tom L van Belle,Ken T Coppieters,Matthias G von Herrath
Tom L van Belle
Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We only know for sure that autoimmunity is the predominant...
Donald E Kohan,Noreen F Rossi,Edward W Inscho et al.
Donald E Kohan et al.
Endothelin (ET) peptides and their receptors are intimately involved in the physiological control of systemic blood pressure and body Na homeostasis, exerting these effects through alterations in a host of circulating and local factors. Hor...
Michael Tri Hoang Do,King-Wai Yau
Michael Tri Hoang Do
Life on earth is subject to alternating cycles of day and night imposed by the rotation of the earth. Consequently, living things have evolved photodetective systems to synchronize their physiology and behavior with the external light-dark ...