Jeffrey R Erickson,B Julie He,Isabella M Grumbach et al.
Jeffrey R Erickson et al.
The multifunctional Ca(2+)- and calmodulin-dependent protein kinase II (CaMKII) is now recognized to play a central role in pathological events in the cardiovascular system. CaMKII has diverse downstream targets that promote vascular diseas...
Danish Sayed,Maha Abdellatif
Danish Sayed
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently introduced an additional level of intricacy to our understanding of gene regulation. There are currently over 10,000 miRNAs that have been identified in a r...
Per Westermark,Arne Andersson,Gunilla T Westermark
Per Westermark
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both locally in the islets, where it inhibits insulin a...
Ernest M Wright,Donald D F Loo,Bruce A Hirayama
Ernest M Wright
There are two classes of glucose transporters involved in glucose homeostasis in the body, the facilitated transporters or uniporters (GLUTs) and the active transporters or symporters (SGLTs). The energy for active glucose transport is prov...
Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation [0.03%]
通过钙粘着蛋白黏附分子的组织重塑：形态发生调节的分子和细胞动态机制
Carien M Niessen,Deborah Leckband,Alpha S Yap
Carien M Niessen
This review addresses the cellular and molecular mechanisms of cadherin-based tissue morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations of cells in organs and tissues. In metazoa, adhesion receptors o...
Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions [0.03%]
哺乳动物环核苷酸磷酸二酯酶：分子机制和生理功能
Sharron H Francis,Mitsi A Blount,Jackie D Corbin
Sharron H Francis
The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11 families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of cellular cN levels and, consequently, the actions of cN-signaling pat...
Epigenetic regulation of gene expression in physiological and pathological brain processes [0.03%]
表观遗传调控在生理和病理脑过程中的基因表达作用
Johannes Gräff,Dohoon Kim,Matthew M Dobbin et al.
Johannes Gräff et al.
Over the past decade, it has become increasingly obvious that epigenetic mechanisms are an integral part of a multitude of brain functions that range from the development of the nervous system over basic neuronal functions to higher order c...
Axon physiology [0.03%]
轴突生理学
Dominique Debanne,Emilie Campanac,Andrzej Bialowas et al.
Dominique Debanne et al.
Axons are generally considered as reliable transmission cables in which stable propagation occurs once an action potential is generated. Axon dysfunction occupies a central position in many inherited and acquired neurological disorders that...
Physiology of microglia [0.03%]
小胶质细胞的生理学
Helmut Kettenmann,Uwe-Karsten Hanisch,Mami Noda et al.
Helmut Kettenmann et al.
Microglial cells are the resident macrophages in the central nervous system. These cells of mesodermal/mesenchymal origin migrate into all regions of the central nervous system, disseminate through the brain parenchyma, and acquire a specif...
Honeybees as a model for the study of visually guided flight, navigation, and biologically inspired robotics [0.03%]
利用视觉引导飞行、导航和生物启发式机器人进行蜜蜂研究模型
Mandyam V Srinivasan
Mandyam V Srinivasan
Research over the past century has revealed the impressive capacities of the honeybee, Apis mellifera, in relation to visual perception, flight guidance, navigation, and learning and memory. These observations, coupled with the relative eas...