Nikolaos G Frangogiannis
Nikolaos G Frangogiannis
The term matricellular proteins describes a family of structurally unrelated extracellular macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue architecture, but are induced following injury and modul...
Shinji Hirano,Masatoshi Takeichi
Shinji Hirano
Cadherins are Ca(2+)-dependent cell-cell adhesion molecules that play critical roles in animal morphogenesis. Various cadherin-related molecules have also been identified, which show diverse functions, not only for the regulation of cell ad...
Jon M Oatley,Ralph L Brinster
Jon M Oatley
This review addresses current understanding of the germline stem cell niche unit in mammalian testes. Spermatogenesis is a classic model of tissue-specific stem cell function relying on self-renewal and differentiation of spermatogonial ste...
The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology [0.03%]
人生理学中分泌蛋白折叠与内质网相关降解的微妙平衡关系研究进展
Christopher J Guerriero,Jeffrey L Brodsky
Christopher J Guerriero
Protein folding is a complex, error-prone process that often results in an irreparable protein by-product. These by-products can be recognized by cellular quality control machineries and targeted for proteasome-dependent degradation. The fo...
100 years since Scott reached the pole: a century of learning about the physiological demands of Antarctica [0.03%]
斯科特到达南极100周年——百年来关于认识南极对人体生理需求的影响方面的心得体会
Lewis G Halsey,Mike A Stroud
Lewis G Halsey
The 1910-1913 Terra Nova Expedition to the Antarctic, led by Captain Robert Falcon Scott, was a venture of science and discovery. It is also a well-known story of heroism and tragedy since his quest to reach the South Pole and conduct resea...
J T Sylvester,Larissa A Shimoda,Philip I Aaronson et al.
J T Sylvester et al.
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last 20 years, it has been clear that the essential sensor, tran...
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan [0.03%]
内吞与信号转导：细胞物流塑造真核细胞结构规划
Sara Sigismund,Stefano Confalonieri,Andrea Ciliberto et al.
Sara Sigismund et al.
Our understanding of endocytosis has evolved remarkably in little more than a decade. This is the result not only of advances in our knowledge of its molecular and biological workings, but also of a true paradigm shift in our understanding ...
Inhibition and termination of physiological responses by GTPase activating proteins [0.03%]
GTP酶激活蛋白对生理反应的抑制和终止作用
Erzsébet Ligeti,Stefan Welti,Klaus Scheffzek
Erzsébet Ligeti
Physiological processes are strictly organized in space and time. However, in cell physiology research, more attention is given to the question of space rather than to time. To function as a signal, environmental changes must be restricted ...
Fast synaptic inhibition in spinal sensory processing and pain control [0.03%]
脊髓感觉处理和疼痛调控中的快速突触抑制作用
Hanns Ulrich Zeilhofer,Hendrik Wildner,Gonzalo E Yévenes
Hanns Ulrich Zeilhofer
The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy conditions, they limit the excitability of spinal terminals of pri...
Physical activity and exercise in the regulation of human adipose tissue physiology [0.03%]
运动和锻炼在人体脂肪组织生理调节中的作用
Dylan Thompson,Fredrik Karpe,Max Lafontan et al.
Dylan Thompson et al.
Physical activity and exercise are key components of energy expenditure and therefore of energy balance. Changes in energy balance alter fat mass. It is therefore reasonable to ask: What are the links between physical activity and adipose t...