Alessandra Boletta,Michael J Caplan
Alessandra Boletta
Polycystic Kidney Disease (PKD) encompasses a class of disorders presenting with bilateral cyst formation in the kidney. PKD can be inherited as a dominant (ADPKD) or a recessive (ARPKD) trait, due to mutations into multiple genes, the most...
Kavaljit H Chhabra,Robin Shoemaker,Chandana B Herath et al.
Kavaljit H Chhabra et al.
Angiotensin Converting Enzyme 2 (ACE2) was discovered 25 years ago as a negative regulator of renin-angiotensin system, opposing the effects of angiotensin-II. Beyond its well-demonstrated roles in cardiovascular regulation and Covid-19 pat...
Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans [0.03%]
人体脂肪组织和骨骼肌中葡萄糖和脂类的代谢性别差异研究
Damla N Costa,Sylvia Santosa,Michael D Jensen
Damla N Costa
Adult males and females have markedly different body composition, energy expenditure, and have different degrees of risk for metabolic diseases. A major aspect of metabolic regulation involves the appropriate storage and disposal of glucose...
Barry E Levin,Nori Geary,Thomas A Lutz
Barry E Levin
Metabolic energy stored mainly as adipose tissue is homeostatically regulated. There is strong evidence that human body weight (BW) is physiologically regulated, i.e. maintained within a relatively narrow range in most mammals, including hu...
Damir Kračun,Lucia R Lopes,Eugenia Cifuentes-Pagano et al.
Damir Kračun et al.
The redox signaling network in mammals has garnered enormous interest and taken on major biological significance in recent years as the scope of NADPH oxidases (NOXs) as regulators of physiological signaling and cellular degeneration has gr...
Kanyada Koysombat,Jovanna Tsoutsouki,Aaran H Patel et al.
Kanyada Koysombat et al.
Kisspeptin and neurokinin B (NKB) play a key role in several physiological processes including in puberty, adult reproductive function including the menstrual cycle, as well as mediating the symptoms of menopause. Infundibular kisspeptin ne...
The TRP Channels Serving as Chemical-to-Electrical Signal Converter [0.03%]
充当化学信号到 electrical signal 转换器的 TRP 频道
Yuhua Tian,Jie Zheng
Yuhua Tian
Biology uses many signaling mechanisms. Among them, calcium and membrane potential are two prominent mediators for cellular signaling. TRPM4 and TRPM5, two calcium-activated monovalent cation-conducting ion channels, offer a direct linkage ...
Motor Control on the Move - from Insights in Insects to General Mechanisms [0.03%]
从昆虫的洞察到一般的机制——运动中的 motor control
Ansgar Büschges,Jan M Ache
Ansgar Büschges
This review discusses how the nervous system controls the complex body movements keeping animals up and running. In particular, we revisit how research in insects has shed light onto motor control principles that govern movements across the...
Jiashuo Zheng 郑嘉烁,Marcus Conrad
Jiashuo Zheng 郑嘉烁
We present here a comprehensive update on recent advancements in the field of ferroptosis, with a particular emphasis on its metabolic underpinnings and physiological impacts. After briefly introducing landmark studies that have helped to s...
Paul M Jenkins,Kevin J Bender
Paul M Jenkins
At the simplest level, neurons are structured to integrate synaptic input and perform computational transforms on that input, converting it into an action potential (AP) code. This process-converting synaptic input into AP output-typically ...