Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors [0.03%]
外周痛觉感受器中缓激肽、二十烷酸衍生物、血小板活化因子和一氧化氮的感觉和信号转导机制
Gábor Petho,Peter W Reeh
Gábor Petho
Peripheral mediators can contribute to the development and maintenance of inflammatory and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two mechanisms. Activation or excitation by these substances of nociceptive ne...
The proprioceptive senses: their roles in signaling body shape, body position and movement, and muscle force [0.03%]
本体感觉：在传达身体形态、位置和运动以及肌肉力量信号中的作用
Uwe Proske,Simon C Gandevia
Uwe Proske
This is a review of the proprioceptive senses generated as a result of our own actions. They include the senses of position and movement of our limbs and trunk, the sense of effort, the sense of force, and the sense of heaviness. Receptors ...
Stem cell factor receptor/c-Kit: from basic science to clinical implications [0.03%]
干细胞因子受体/CD117:c-KIT：从基础科学到临床意义
Johan Lennartsson,Lars Rönnstrand
Johan Lennartsson
Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its autophosphorylation and initiation of signal transduction. S...
Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport [0.03%]
SPAK和OSR1的分子生理学：两种调节离子转运的Ste20相关蛋白激酶
Kenneth B Gagnon,Eric Delpire
Kenneth B Gagnon
SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 (Sterile20)-related protein kinase family. Although there are 30 en...
Evolution of placental function in mammals: the molecular basis of gas and nutrient transfer, hormone secretion, and immune responses [0.03%]
哺乳动物胎盘功能的进化：气体和营养物质转移、激素分泌以及免疫反应的分子基础
Anthony M Carter
Anthony M Carter
Placenta has a wide range of functions. Some are supported by novel genes that have evolved following gene duplication events while others require acquisition of gene expression by the trophoblast. Although not expressed in the placenta, hi...
Shelly C Lu,José M Mato
Shelly C Lu
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver. Biosynthesis of AdoMet requires the enzyme methionine adenosyltransferas...
Jamie I Vandenberg,Matthew D Perry,Mark J Perrin et al.
Jamie I Vandenberg et al.
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which are expressed in the heart, various brain regions, smooth muscle cells, endocrine cells...
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism [0.03%]
Sir2家族成员Sirt1和Sirt3的生理功能及其对代谢的调节作用
Ruben Nogueiras,Kirk M Habegger,Nilika Chaudhary et al.
Ruben Nogueiras et al.
The sirtuins are a family of highly conserved NAD(+)-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are...
Luc Leybaert,Michael J Sanderson
Luc Leybaert
Intercellular calcium (Ca(2+)) waves (ICWs) represent the propagation of increases in intracellular Ca(2+) through a syncytium of cells and appear to be a fundamental mechanism for coordinating multicellular responses. ICWs occur in a wide ...
Elise Balse,David F Steele,Hugues Abriel et al.
Elise Balse et al.
Cardiac myocytes are characterized by distinct structural and functional entities involved in the generation and transmission of the action potential and the excitation-contraction coupling process. Key to their function is the specific org...