Urothelial signaling [0.03%]
尿路上皮信号转导
Lori Birder,Karl-Erik Andersson
Lori Birder
The urothelium, which lines the inner surface of the renal pelvis, the ureters, and the urinary bladder, not only forms a high-resistance barrier to ion, solute and water flux, and pathogens, but also functions as an integral part of a sens...
Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family [0.03%]
电压门控质子通道：H(v)家族的分子生物学、生理学和病理生理学
Thomas E DeCoursey
Thomas E DeCoursey
Voltage-gated proton channels (H(V)) are unique, in part because the ion they conduct is unique. H(V) channels are perfectly selective for protons and have a very small unitary conductance, both arguably manifestations of the extremely low ...
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity [0.03%]
生长激素信号转导：生长、生殖发育和寿命之间的权衡关系
Andrzej Bartke,Liou Y Sun,Valter Longo
Andrzej Bartke
Growth hormone (GH) is a key determinant of postnatal growth and plays an important role in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling delays aging and remarkably extends longevity in laboratory...
Dorothee Günzel,Alan S L Yu
Dorothee Günzel
Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large pro...
Yuuki Imai,Min-Young Youn,Kazuki Inoue et al.
Yuuki Imai et al.
During the last decade, our view on the skeleton as a mere solid physical support structure has been transformed, as bone emerged as a dynamic, constantly remodeling tissue with systemic regulatory functions including those of an endocrine ...
R A D Bathgate,M L Halls,E T van der Westhuizen et al.
R A D Bathgate et al.
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has many roles in female and male reproduction, as a neuropeptide in the central nervous system, as a vasodilator and cardiac stimulant in the car...
André Tchernof,Jean-Pierre Després
André Tchernof
Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic triglyceride storage closely related to clustering cardiomet...
New fundamentals in hemostasis [0.03%]
凝血的新观点
Henri H Versteeg,Johan W M Heemskerk,Marcel Levi et al.
Henri H Versteeg et al.
Hemostasis encompasses the tightly regulated processes of blood clotting, platelet activation, and vascular repair. After wounding, the hemostatic system engages a plethora of vascular and extravascular receptors that act in concert with bl...
Eric M Green,Richard T Lee
Eric M Green
Regenerative medicine seeks to understand tissue development and homeostasis and build on that knowledge to enhance regeneration of injured tissues. By replenishing lost functional tissues and cells, regenerative medicine could change the t...
Jacqueline Cherfils,Mahel Zeghouf
Jacqueline Cherfils
Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate dissociation of the tightly bound GDP, and turned off by GAPs, whi...