Che-Hong Chen,Julio Cesar Batista Ferreira,Eric R Gross et al.
Che-Hong Chen et al.
A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that accumulate through metabolism and to which we are exposed from the environment has been ...
Helle H Damkier,Peter D Brown,Jeppe Praetorius
Helle H Damkier
The choroid plexus epithelium is a cuboidal cell monolayer, which produces the majority of the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins mediates the transepithelial movement of solutes and water a...
Alexander A Boldyrev,Giancarlo Aldini,Wim Derave
Alexander A Boldyrev
Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal muscle, but also in other excitable tissues. Most animals, except humans, ...
Postischemic revascularization: from cellular and molecular mechanisms to clinical applications [0.03%]
缺血后的再血管化：从细胞和分子机制到临床应用
Jean-Sébastien Silvestre,David M Smadja,Bernard I Lévy
Jean-Sébastien Silvestre
After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular, cellular, and extracellular responses that determine the function and the remodeling of the ischemic tissue. Hypoxia-related pathways, immunoinflamm...
Systemic iron homeostasis [0.03%]
铁稳态的研究进展
Tomas Ganz
Tomas Ganz
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron...
Small G proteins in the cardiovascular system: physiological and pathological aspects [0.03%]
小G蛋白在心血管系统中的生理和病理作用
Gervaise Loirand,Vincent Sauzeau,Pierre Pacaud
Gervaise Loirand
Small G proteins exist in eukaryotes from yeast to human and constitute the Ras superfamily comprising more than 100 members. This superfamily is structurally classified into five families: the Ras, Rho, Rab, Arf, and Ran families that cont...
Robert J Vandenberg,Renae M Ryan
Robert J Vandenberg
L-Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system and plays important roles in a wide variety of brain functions, but it is also a key player in the pathogenesis of many neurological disorder...
Paul Avan,Béla Büki,Christine Petit
Paul Avan
To enhance weak sounds while compressing the dynamic intensity range, auditory sensory cells amplify sound-induced vibrations in a nonlinear, intensity-dependent manner. In the course of this process, instantaneous waveform distortion is pr...
Erlend A Nagelhus,Ole P Ottersen
Erlend A Nagelhus
Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. While AQP4 has been implicated in a number of pathophysiological pro...
Paul N Hopkins
Paul N Hopkins
At least 468 individual genes have been manipulated by molecular methods to study their effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and many investigators, even in related disciplines, find many...