Richard L Eckert,Mari T Kaartinen,Maria Nurminskaya et al.
Richard L Eckert et al.
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease. This...
Rashmi Mullur,Yan-Yun Liu,Gregory A Brent
Rashmi Mullur
Thyroid hormone (TH) is required for normal development as well as regulating metabolism in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially expressed in tissues and have distinct roles in TH signaling. L...
Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases [0.03%]
氧化应激：胃肠黏膜疾病发病机制的关键因素
Asima Bhattacharyya,Ranajoy Chattopadhyay,Sankar Mitra et al.
Asima Bhattacharyya et al.
Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes involved in protecting cells from the damaging effects of ROS. RO...
L-type CaV1.2 calcium channels: from in vitro findings to in vivo function [0.03%]
L型CaV1.2钙通道：从体外发现到体内功能
Franz Hofmann,Veit Flockerzi,Sabine Kahl et al.
Franz Hofmann et al.
The L-type Cav1.2 calcium channel is present throughout the animal kingdom and is essential for some aspects of CNS function, cardiac and smooth muscle contractility, neuroendocrine regulation, and multiple other processes. The L-type CaV1....
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease [0.03%]
缓激肽及其受体在生理调节及疾病机制中的作用
Martin S Steinhoff,Bengt von Mentzer,Pierangelo Geppetti et al.
Martin S Steinhoff et al.
The tachykinins, exemplified by substance P, are one of the most intensively studied neuropeptide families. They comprise a series of structurally related peptides that derive from alternate processing of three Tac genes and are expressed t...
Laurent Blanchoin,Rajaa Boujemaa-Paterski,Cécile Sykes et al.
Laurent Blanchoin et al.
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton drives a large range of cellular processes including polarity establishment, morphogenesis, and motility. This is possible because actin filaments are se...
Alessandro Sale,Nicoletta Berardi,Lamberto Maffei
Alessandro Sale
Brain plasticity refers to the remarkable property of cerebral neurons to change their structure and function in response to experience, a fundamental theoretical theme in the field of basic research and a major focus for neural rehabilitat...
Carlo Sala,Menahem Segal
Carlo Sala
The introduction of high-resolution time lapse imaging and molecular biological tools has changed dramatically the rate of progress towards the understanding of the complex structure-function relations in synapses of central spiny neurons. ...
Emmanuel Bourinet,Christophe Altier,Michael E Hildebrand et al.
Emmanuel Bourinet et al.
The detection and processing of painful stimuli in afferent sensory neurons is critically dependent on a wide range of different types of voltage- and ligand-gated ion channels, including sodium, calcium, and TRP channels, to name a few. Th...
Markus Ullsperger,Claudia Danielmeier,Gerhard Jocham
Markus Ullsperger
Successful goal-directed behavior requires not only correct action selection, planning, and execution but also the ability to flexibly adapt behavior when performance problems occur or the environment changes. A prerequisite for determining...