Luke H Chamberlain,Michael J Shipston
Luke H Chamberlain
Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is emerging as a ubiquitous mechanism to control the properties and function of a diverse array of proteins and consequently physiological proc...
Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited [0.03%]
上皮钠通道及其醛固酮介导的调节：我们体内环境的故事再探
Bernard C Rossier,Michael E Baker,Romain A Studer
Bernard C Rossier
Transcription and translation require a high concentration of potassium across the entire tree of life. The conservation of a high intracellular potassium was an absolute requirement for the evolution of life on Earth. This was achieved by ...
Kyle M Loh,Bing Lim,Lay Teng Ang
Kyle M Loh
Pluripotent cells in embryos are situated near the apex of the hierarchy of developmental potential. They are capable of generating all cell types of the mammalian body proper. Therefore, they are the exemplar of stem cells. In vivo, plurip...
Electronic connection between the quinone and cytochrome C redox pools and its role in regulation of mitochondrial electron transport and redox signaling [0.03%]
醌和细胞色素C氧化还原池之间的电子连接及其在调节线粒体电子传递和氧化还原信号中的作用
Marcin Sarewicz,Artur Osyczka
Marcin Sarewicz
Mitochondrial respiration, an important bioenergetic process, relies on operation of four membranous enzymatic complexes linked functionally by mobile, freely diffusible elements: quinone molecules in the membrane and water-soluble cytochro...
Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels [0.03%]
K2P和Kir钾转运通道的分子结构、调控与生理学：酸敏感性背景钾通道研究进展
Francisco V Sepúlveda,L Pablo Cid,Jacques Teulon et al.
Francisco V Sepúlveda et al.
K(+) channels fulfill roles spanning from the control of excitability to the regulation of transepithelial transport. Here we review two groups of K(+) channels, pH-regulated K2P channels and the transport group of Kir channels. After consi...
Vinicius Motta,Fraser Soares,Tian Sun et al.
Vinicius Motta et al.
Nucleotide binding oligomerization domain (NOD)-like receptors are cytoplasmic pattern-recognition receptors that together with RIG-I-like receptor (retinoic acid-inducible gene 1), Toll-like receptor (TLR), and C-type lectin families make ...
Yanxia Guo,Chrysothemis Brown,Carla Ortiz et al.
Yanxia Guo et al.
Although vitamin A was recognized as an "anti-infective vitamin" over 90 years ago, the mechanism of how vitamin A regulates immunity is only beginning to be understood. Early studies which focused on the immune responses in vitamin A-defic...
The organic anion transporter (OAT) family: a systems biology perspective [0.03%]
有机阴离子转运蛋白(OAT)家族：系统生物学视角
Sanjay K Nigam,Kevin T Bush,Gleb Martovetsky et al.
Sanjay K Nigam et al.
The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention because of its role in handling of common drugs (antibiotics, antivira...
Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity [0.03%]
影响能量和葡萄糖稳态及肥胖发育起源的基因-环境相互作用
Sebastien Bouret,Barry E Levin,Susan E Ozanne
Sebastien Bouret
Obesity and type 2 diabetes mellitus (T2DM) often occur together and affect a growing number of individuals in both the developed and developing worlds. Both are associated with a number of other serious illnesses that lead to increased rat...
Jeroen H F de Baaij,Joost G J Hoenderop,René J M Bindels
Jeroen H F de Baaij
Magnesium (Mg(2+)) is an essential ion to the human body, playing an instrumental role in supporting and sustaining health and life. As the second most abundant intracellular cation after potassium, it is involved in over 600 enzymatic reac...