Uterine Fibroids [0.03%]
子宫肌瘤
Serdar E Bulun,Ping Yin,Jian-Jun Wei et al.
Serdar E Bulun et al.
Uterine fibroids (leiomyomas), the most common tumors in women and those assigned female at birth, originate from myometrial smooth muscle cells and cause heavy menstrual bleeding, anemia, pelvic discomfort, pregnancy loss, and obstruction ...
TPCs: From plant to human [0.03%]
TPC：从植物到人类
Yvonne Eileen Klingl,Arnas Petrauskas,Dawid Jaślan et al.
Yvonne Eileen Klingl et al.
In 2005, the Arabidopsis thaliana two-pore channel TPC1 channel was identified as a vacuolar Ca²⁺-release channel. In 2009 three independent groups published studies on mammalian TPCs as NAADP-activated endolysosomal Ca2+ release channels...
A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise [0.03%]
肌糖原吸收的全面观点：胰岛素、收缩活动和运动的影响
Erik A Richter,Philip J Bilan,Amira Klip
Erik A Richter
Skeletal muscle is the main site of glucose deposition in the body during meals and the major glucose utilizer during physical activity. While in both instances the supply of glucose from the circulation to the muscle is of paramount import...
Extracellular vesicles and lung disease: from pathogenesis to biomarkers and treatments [0.03%]
胞外囊泡与肺部疾病：从发病机理到生物标志物和治疗应用查看答案
Kyong-Su Park,Cecilia Lässer,Jan Lötvall
Kyong-Su Park
Nanosized extracellular vesicles (EVs) are released by all cells to convey cell-to-cell communication. EVs, including exosomes and microvesicles, carry an array of bioactive molecules, such as proteins and RNAs, encapsulated by a membrane l...
Biomarkers of aging: from molecules and surrogates to physiology and function [0.03%]
衰老的生物标志物：从分子和替代物到生理学和功能的变化
Regula Furrer,Christoph Handschin
Regula Furrer
Many countries face an unprecedented challenge in aging demographics. This has led to an exponential growth in research of aging, which, coupled to a massive financial influx of funding in the private and public sectors, has resulted in sem...
Transforming the concept of connectivity: unveiling tunneling nanotube biology, and their roles in brain development and neurodegeneration [0.03%]
连接性概念的转变：揭示穿隧纳米管生物学及其在大脑发育和神经退行性疾病中的作用
Francesca Palese,Malalaniaina Rakotobe,Chiara Zurzolo
Francesca Palese
Tunneling nanotubes (TNTs) are thin tubular membrane protrusions that connect distant cells, generating a complex cellular network. Over the past few decades, research on TNTs has provided important insights into their biology, including st...
Neuropathological links between T2DM and LOAD: systematic review and meta-analysis [0.03%]
2型糖尿病与晚发性阿尔茨海默病之间的神经病理联系：系统回顾和荟萃分析
Erwin Lemche,Tibor Hortobágyi,Clemens Kiecker et al.
Erwin Lemche et al.
Recent decades have described in-parallel neuropathological mechanisms, increasing the risk for developing late-onset Alzheimer's dementia (LOAD) in type 2 diabetes mellitus (T2DM), however, still little is known of the role of diabetic enc...
Ariel Jaitovich,Jesse B Hall
Ariel Jaitovich
During critical illness, systemic inflammation causes organ-specific metabolic changes. In the immune and inflammatory compartments, predominantly anabolic reprogramming supports cellular replication and inflammatory response execution. Par...
The influence of extracellular vesicles on tumor evolution and resistance to therapy [0.03%]
胞外囊泡对肿瘤演变及抗治疗抵抗性的影响
Enrique Bastón,Juan García-Agulló,Héctor Peinado
Enrique Bastón
Disruption of cellular communication that regulates normal physiology is often key factor in the development of disease, including cancer. Extracellular vesicles (EVs) are mediators of cell-cell communication, modulating local and distant m...
The pathogenesis of cerebral small vessel diseases and vascular cognitive impairment [0.03%]
脑小血管病与血管性认知障碍的发生机制
Hugh S Markus,Anne Joutel
Hugh S Markus
Cerebral small vessel disease (cSVD) is the broadly accepted term nowadays to designate a heterogeneous group of diseases caused by in situ damages of small brain vessels commonly related to aging, hypertension or genetic factors. Cardinal ...