Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality [0.03%]
肥胖与糖尿病的癌症风险及癌症相关死亡率的增加
Emily Jane Gallagher,Derek LeRoith
Emily Jane Gallagher
Obesity and type 2 diabetes are becoming increasingly prevalent worldwide, and both are associated with an increased incidence and mortality from many cancers. The metabolic abnormalities associated with type 2 diabetes develop many years b...
Neuroglial Transmission [0.03%]
神经胶质传递
Vidar Gundersen,Jon Storm-Mathisen,Linda Hildegard Bergersen
Vidar Gundersen
Neuroglia, the "glue" that fills the space between neurons in the central nervous system, takes active part in nerve cell signaling. Neuroglial cells, astroglia, oligodendroglia, and microglia, are together about as numerous as neurons in t...
Reply to O'Grady et al [0.03%]
致O'Grady等人一函
Kenton M Sanders,Sean M Ward,Sang Don Koh
Kenton M Sanders
Gregory O&#x;Grady,Timothy Angeli,Peng Du et al.
Gregory O&#x;Grady et al.
Scott Earley,Joseph E Brayden
Scott Earley
The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species. Multiple TRP channels are present in all ce...
Yuri L Dorokhov,Anastasia V Shindyapina,Ekaterina V Sheshukova et al.
Yuri L Dorokhov et al.
Methanol has been historically considered an exogenous product that leads only to pathological changes in the human body when consumed. However, in normal, healthy individuals, methanol and its short-lived oxidized product, formaldehyde, ar...
Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs [0.03%]
运动期间肌肉血流增加（充血）的调节：生理需求竞争的层级体系
Michael J Joyner,Darren P Casey
Michael J Joyner
This review focuses on how blood flow to contracting skeletal muscles is regulated during exercise in humans. The idea is that blood flow to the contracting muscles links oxygen in the atmosphere with the contracting muscles where it is con...
Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease [0.03%]
胰高血糖素原肽的生理作用：胰高血糖素和GLP-1在健康与疾病中的作用
Darleen A Sandoval,David A D&#x;Alessio
Darleen A Sandoval
The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the nucleus of the solitary tract. Gcg encodes multiple peptide...
Mattias Carlström,Christopher S Wilcox,William J Arendshorst
Mattias Carlström
Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80-180 mmHg). Such autoregulation is mediated largely by the myoge...
The evolving impact of g protein-coupled receptor kinases in cardiac health and disease [0.03%]
G蛋白偶联受体激酶在心脏健康和疾病中影响的演变
Priscila Y Sato,J Kurt Chuprun,Mathew Schwartz et al.
Priscila Y Sato et al.
G protein-coupled receptors (GPCRs) are important regulators of various cellular functions via activation of intracellular signaling events. Active GPCR signaling is shut down by GPCR kinases (GRKs) and subsequent β-arrestin-mediated mecha...