Martin Korte,Dietmar Schmitz
Martin Korte
The storage of information in the mammalian nervous systems is dependent on a delicate balance between change and stability of neuronal networks. The induction and maintenance of processes that lead to changes in synaptic strength to a mult...
Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane [0.03%]
到达外叶层：关于质膜上磷脂酰丝氨酸暴露的生理学研究
Edouard M Bevers,Patrick L Williamson
Edouard M Bevers
Phosphatidylserine (PS) is a major component of membrane bilayers whose change in distribution between inner and outer leaflets is an important physiological signal. Normally, members of the type IV P-type ATPases spend metabolic energy to ...
Jude S Morton,Christy-Lynn Cooke,Sandra T Davidge
Jude S Morton
The developmental origins of health and disease theory is based on evidence that a suboptimal environment during fetal and neonatal development can significantly impact the evolution of adult-onset disease. Abundant evidence exists that a c...
Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery [0.03%]
哺乳动物孕期、泌乳期及断奶后的母体矿物和骨代谢
Christopher S Kovacs
Christopher S Kovacs
During pregnancy and lactation, female physiology adapts to meet the added nutritional demands of fetuses and neonates. An average full-term fetus contains ∼30 g calcium, 20 g phosphorus, and 0.8 g magnesium. About 80% of mineral is accret...
Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy [0.03%]
糖皮质激素在软骨和骨骼健康、疾病和类固醇治疗期间的分子作用机制
Kerstin Hartmann,Mascha Koenen,Sebastian Schauer et al.
Kerstin Hartmann et al.
Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that are frequently used to treat inflammatory diseases. Major complications associated with long-term steroid therapy include impairment of cartilaginous b...
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects [0.03%]
维生素D：代谢、分子机制及其多效作用
Sylvia Christakos,Puneet Dhawan,Annemieke Verstuyf et al.
Sylvia Christakos et al.
1,25-Dihydroxvitamin D3 [1,25(OH)2D3] is the hormonally active form of vitamin D. The genomic mechanism of 1,25(OH)2D3 action involves the direct binding of the 1,25(OH)2D3 activated vitamin D receptor/retinoic X receptor (VDR/RXR) heterodi...
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications [0.03%]
抗氧化酶的矛盾作用：基本机制及健康影响
Xin Gen Lei,Jian-Hong Zhu,Wen-Hsing Cheng et al.
Xin Gen Lei et al.
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes. Because ROS/RNS can induce oxidative injury and ac...
Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy [0.03%]
dystrophin缺失扰乱骨骼肌信号转导：Ca2+、活性氧和一氧化氮在肌营养不良发病机制中的作用
David G Allen,Nicholas P Whitehead,Stanley C Froehner
David G Allen
Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further connections via laminin to other extracellular matrix pro...
Monique N Foster,William A Coetzee
Monique N Foster
KATP channels are integral to the functions of many cells and tissues. The use of electrophysiological methods has allowed for a detailed characterization of KATP channels in terms of their biophysical properties, nucleotide sensitivities, ...
Philippe Besnard,Patricia Passilly-Degrace,Naim A Khan
Philippe Besnard
An attraction for palatable foods rich in lipids is shared by rodents and humans. Over the last decade, the mechanisms responsible for this specific eating behavior have been actively studied, and compelling evidence implicates a taste comp...