Rebuilding the Damaged Heart: Mesenchymal Stem Cells, Cell-Based Therapy, and Engineered Heart Tissue [0.03%]
修复损伤的心脏：间充质干细胞、基于细胞的疗法和工程心脏组织
Samuel Golpanian,Ariel Wolf,Konstantinos E Hatzistergos et al.
Samuel Golpanian et al.
Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an array of anti-inflammatory and anti-fibrotic mediators, an...
Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine [0.03%]
人诱导多能干细胞在个性化和精确心血管医学中的应用
Elena Matsa,John H Ahrens,Joseph C Wu
Elena Matsa
Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human disease modeling, with an enormous potential to serve as paradigm shifting platforms for preclinical trials, personalized clinical diagnosis, and drug trea...
Laura Stransky,Kristina Cotter,Michael Forgac
Laura Stransky
The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis to proton transport into intracellular compartments and across the plasma membrane. They function in a wide array of normal cellular processes, includi...
Stuart B Mazzone,Bradley J Undem
Stuart B Mazzone
Vagal sensory neurons constitute the major afferent supply to the airways and lungs. Subsets of afferents are defined by their embryological origin, molecular profile, neurochemistry, functionality, and anatomical organization, and collecti...
John P M White,Mario Cibelli,Laszlo Urban et al.
John P M White et al.
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol 2: 695-702, 2000) and Liedtke (Cell 103: 525-535, 2000). ...
Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics [0.03%]
女性生育能力的生理学方面：环境、现代生活方式和遗传的作用
Roger J Hart
Roger J Hart
Across the Western World there is an increasing trend to postpone childbearing. Consequently, the negative influence of age on oocyte quality may lead to a difficulty in conceiving for many couples. Furthermore, lifestyle factors may exacer...
Parathyroid Hormone-Related Protein, Its Regulation of Cartilage and Bone Development, and Role in Treating Bone Diseases [0.03%]
甲状旁腺激素相关蛋白对软骨和骨骼发育的调控及其在治疗骨病中的作用
T John Martin
T John Martin
Although parathyroid hormone-related protein (PTHrP) was discovered as a cancer-derived hormone, it has been revealed as an important paracrine/autocrine regulator in many tissues, where its effects are context dependent. Thus its location ...
Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling [0.03%]
临床癌症治疗的获得性耐药：生理信号通路中的一个转折点
Andreas Wicki,Mario Mandalà,Daniela Massi et al.
Andreas Wicki et al.
Although modern therapeutic strategies have brought significant progress to cancer care in the last 30 years, drug resistance to targeted monotherapies has emerged as a major challenge. Aberrant regulation of multiple physiological signalin...
Michaela Kuhn
Michaela Kuhn
cGMP controls many cellular functions ranging from growth, viability, and differentiation to contractility, secretion, and ion transport. The mammalian genome encodes seven transmembrane guanylyl cyclases (GCs), GC-A to GC-G, which mainly m...
Fear Memory [0.03%]
恐惧记忆
Ivan Izquierdo,Cristiane R G Furini,Jociane C Myskiw
Ivan Izquierdo
Fear memory is the best-studied form of memory. It was thoroughly investigated in the past 60 years mostly using two classical conditioning procedures (contextual fear conditioning and fear conditioning to a tone) and one instrumental proce...