Type I Interferons in health and disease-Molecular aspects and clinical implications [0.03%]
I型干扰素的分子特征及其在健康和疾病中的临床意义
Clio P Mavragani,Mary K Crow
Clio P Mavragani
Type I interferons (IFNs), particularly IFNα and IFNβ, play a crucial role in the human immune response against viral infections. This review delves into the multifaceted antiviral, immunomodulatory and antitumor physiological roles of ty...
Programmed cell death and tissue regeneration: A link that should be resolved [0.03%]
程序性细胞死亡与组织再生：亟待解决的关联问题
Gelina S Kopeina,Anastasia Yu Efimenko,Vsevolod A Tkachuk et al.
Gelina S Kopeina et al.
Cellular homeostasis is maintained by three important physiological processes: proliferation, characterized by an increase in cell number; differentiation, characterized by either an increase or decrease in cell number coincident with chang...
Irving L M H Aye,Stephen Tong,D Stephen Charnock-Jones et al.
Irving L M H Aye et al.
The placenta performs many key tasks which are essential for healthy growth and development of the human fetus. Placental dysfunction has multiple manifestations but they share the common property of lacking mechanistic understanding of eti...
Yves-Alain Barde
Yves-Alain Barde
BDNF is synthesized and secreted by excitatory neurons. Decades of work with animal models prepared the ground for interpreting the results of human genome analyses associating polymorphisms with memory deficits, mood disorders and dysregul...
Glycerolipid Cycling in Thermogenesis, Energy Homeostasis and Signaling [0.03%]
甘油磷脂在产热、能量平衡和信号传导中的循环作用
Pegah Poursharifi,S R Murthy Madiraju,Abel Oppong et al.
Pegah Poursharifi et al.
Mammals maintain body heat by adaptive energy expenditure through different organ specific mechanisms. The glycerolipid/free fatty acid cycle (glycerolipid cycle), encompassing triglyceride lipolysis and free fatty acid (FFA) release follow...
Immunomodulatory properties of transmembrane mucins: from chronic diseases to cancer [0.03%]
跨膜黏蛋白的免疫调节特性：从慢性疾病到癌症
Paula Montero,Inés Roger,Javier Milara et al.
Paula Montero et al.
Mucins are large glycoproteins that form the primary structural component of mucus and can be classified into secreted and transmembrane types. Of the 22 identified mucin genes, 12 encode transmembrane mucins, which play crucial roles in ma...
Weirui Zhang,Svenja Koslowski,Marouane Benzaki et al.
Weirui Zhang et al.
Genome-wide association studies (GWAS) have identified numerous common genetic variants associated with cardiovascular traits and diseases. These studies have increased our understanding of the genetic architecture of cardiac diseases and h...
Claudia Monaco,Coleen A McNamara,Bram Slütter et al.
Claudia Monaco et al.
Cardiovascular disease is the global #1 cause of mortality and morbidity. The majority of cardiovascular diseases is caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The disease is cha...
Yumei Feng Earley,Shiyue Pan,Himanshu Verma et al.
Yumei Feng Earley et al.
Salt-sensitive and salt-induced hypertension (SHTN) is a multifaceted and heterogeneous condition influenced by various factors, including lifestyles, genetics, sex, age, and dietary salt intake. Despite its prevalence - affecting about 50%...