Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection [0.03%]
细菌与宿主的相互作用：呼吸道感染的生理和病理生理学
A P Hakansson,C J Orihuela,D Bogaert
A P Hakansson
It has long been thought that respiratory infections are the direct result of acquisition of pathogenic viruses or bacteria, followed by their overgrowth, dissemination, and in some instances tissue invasion. In the last decades, it has bec...
Maysa Sarhan,Walter G Land,Wulf Tonnus et al.
Maysa Sarhan et al.
When cells undergo necrotic cell death in either physiological or pathophysiological settings in vivo, they release highly immunogenic intracellular molecules and organelles into the interstitium and thereby represent the strongest known tr...
Folami Y Ideraabdullah,Steven H Zeisel
Folami Y Ideraabdullah
Epigenetics is the study of heritable mechanisms that can modify gene activity and phenotype without modifying the genetic code. The basis for the concept of epigenetics originated more than 2,000 yr ago as a theory to explain organismal de...
Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases [0.03%]
药 pharmacoperone作为一种治疗多种蛋白质构象性疾病的新型疗法
Ya-Xiong Tao,P Michael Conn
Ya-Xiong Tao
After synthesis, proteins are folded into their native conformations aided by molecular chaperones. Dysfunction in folding caused by genetic mutations in numerous genes causes protein conformational diseases. Membrane proteins are more pron...
Natalia Prevarskaya,Roman Skryma,Yaroslav Shuba
Natalia Prevarskaya
Genomic instability is a primary cause and fundamental feature of human cancer. However, all cancer cell genotypes generally translate into several common pathophysiological features, often referred to as cancer hallmarks. Although nowadays...
R William Caldwell,Paulo C Rodriguez,Haroldo A Toque et al.
R William Caldwell et al.
The arginase enzyme developed in early life forms and was maintained during evolution. As the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The urea cycle provides protection against excess ammonia, ...
PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer [0.03%]
PTX3在先天免疫、组织修复和癌症中的作用：一种补体模式识别分子
Cecilia Garlanda,Barbara Bottazzi,Elena Magrini et al.
Cecilia Garlanda et al.
Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern recognition molecule conserved in evolution which acts as a key component of humoral innate immunity in infections of fungal, bacterial, and viral origin. ...
In the Shadow of Giants: Challenges and Opportunities for the New Editor of Physiological Reviews [0.03%]
巨人的阴影：生理学评论新主编的挑战与机遇
Sadis Matalon
Sadis Matalon
Understanding Key Mechanisms of Exercise-Induced Cardiac Protection to Mitigate Disease: Current Knowledge and Emerging Concepts [0.03%]
理解运动诱导的心脏保护的关键机制以减轻疾病：当前知识和新兴概念
Bianca C Bernardo,Jenny Y Y Ooi,Kate L Weeks et al.
Bianca C Bernardo et al.
The benefits of exercise on the heart are well recognized, and clinical studies have demonstrated that exercise is an intervention that can improve cardiac function in heart failure patients. This has led to significant research into unders...
The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7) [0.03%]
肾素血管紧张素系统中的ACE2/血管紧张素-(1-7)/MAS轴：关于血管紧张素-(1-7)的焦点研究
Robson Augusto Souza Santos,Walkyria Oliveira Sampaio,Andreia C Alzamora et al.
Robson Augusto Souza Santos et al.
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and hydroelectrolyte balance, with an influence on organs and functions throughout the body. The classical view of this system saw it as a sequen...