Charles A Ducsay,Ravi Goyal,William J Pearce et al.
Charles A Ducsay et al.
Hypoxia is one of the most common and severe challenges to the maintenance of homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is multidimensional involving complicated intracellular networks concerned w...
Luc Baeyens,Marie Lemper,Willem Staels et al.
Luc Baeyens et al.
Diabetes mellitus results from disturbed glucose homeostasis due to an absolute (type 1) or relative (type 2) deficiency of insulin, a peptide hormone almost exclusively produced by the beta cells of the endocrine pancreas in a tightly regu...
Myoediting: Toward Prevention of Muscular Dystrophy by Therapeutic Genome Editing [0.03%]
肌编辑学：利用治疗性基因组编辑预防肌肉营养不良
Yu Zhang,Chengzu Long,Rhonda Bassel-Duby et al.
Yu Zhang et al.
Muscular dystrophies represent a large group of genetic disorders that significantly impair quality of life and often progress to premature death. There is no effective treatment for these debilitating diseases. Most therapies, developed to...
Specialized Proresolving Mediators in Innate and Adaptive Immune Responses in Airway Diseases [0.03%]
呼吸道疾病中固有免疫和适应性免疫反应的专业化解剂调解机制研究
Nandini Krishnamoorthy,Raja-Elie E Abdulnour,Katherine H Walker et al.
Nandini Krishnamoorthy et al.
Airborne pathogens and environmental stimuli evoke immune responses in the lung. It is critical to health that these responses be controlled to prevent tissue damage and the compromise of organ function. Resolution of inflammation is a dyna...
Florent Elefteriou
Florent Elefteriou
It is from the discovery of leptin and the central nervous system as a regulator of bone remodeling that the presence of autonomic nerves within the skeleton transitioned from a mere histological observation to the mechanism whereby neurons...
Werd Al-Najim,Neil G Docherty,Carel W le Roux
Werd Al-Najim
Obesity is an escalating global chronic disease. Bariatric surgery is a very efficacious treatment for obesity and its comorbidities. Alterations to gastrointestinal anatomy during bariatric surgery result in neurological and physiological ...
Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development [0.03%]
胞内cAMP受体EPAC的生理、病理和药理学研究进展
William G Robichaux rd,Xiaodong Cheng
William G Robichaux rd
This review focuses on one family of the known cAMP receptors, the exchange proteins directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide exchange factors (cAMP-GEFs). Although EPAC proteins are fairly new...
The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis [0.03%]
神经调节蛋白和炎症及髓系细胞依赖性血管生成的介质
Lucia Negri,Napoleone Ferrara
Lucia Negri
The mammalian prokineticins family comprises two conserved proteins, EG-VEGF/PROK1 and Bv8/PROK2, and their two highly related G protein-coupled receptors, PKR1 and PKR2. This signaling system has been linked to several important biological...
Amanda Phuong Tran,Philippa Mary Warren,Jerry Silver
Amanda Phuong Tran
Since no approved therapies to restore mobility and sensation following spinal cord injury (SCI) currently exist, a better understanding of the cellular and molecular mechanisms following SCI that compromise regeneration or neuroplasticity ...
Neuronal Cell Death [0.03%]
神经元细胞死亡
Michael Fricker,Aviva M Tolkovsky,Vilmante Borutaite et al.
Michael Fricker et al.
Neuronal cell death occurs extensively during development and pathology, where it is especially important because of the limited capacity of adult neurons to proliferate or be replaced. The concept of cell death used to be simple as there w...