Jenny van der Wijst,Hendrica Belge,René J M Bindels et al.
Jenny van der Wijst et al.
The identification of genes causing inherited kidney diseases yielded crucial insights in the molecular basis of disease and improved our understanding of physiological processes that operate in the kidney. Monogenic kidney disorders are ca...
Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina [0.03%]
脊椎动物视网膜中色彩视觉的多种细胞类型、回路和机制
Wallace B Thoreson,Dennis M Dacey
Wallace B Thoreson
Synaptic interactions to extract information about wavelength, and thus color, begin in the vertebrate retina with three classes of light-sensitive cells: rod photoreceptors at low light levels, multiple types of cone photoreceptors that va...
Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation [0.03%]
穿越血管屏障：控制 extravasation 的内皮细胞信号转导过程
Nina Wettschureck,Boris Strilic,Stefan Offermanns
Nina Wettschureck
A central function of the vascular endothelium is to serve as a barrier between the blood and the surrounding tissue of the body. At the same time, solutes and cells have to pass the endothelium to leave or to enter the bloodstream to maint...
Myelin in the Central Nervous System: Structure, Function, and Pathology [0.03%]
中枢神经系统的髓鞘：结构、功能和病理学
Christine Stadelmann,Sebastian Timmler,Alonso Barrantes-Freer et al.
Christine Stadelmann et al.
Oligodendrocytes generate multiple layers of myelin membrane around axons of the central nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve conduction was considered the only purpose of myelin, but...
FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [0.03%]
FLT3酪氨酸激酶的作用机制及临床意义研究从基础到临床
Julhash U Kazi,Lars Rönnstrand
Julhash U Kazi
FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activi...
Luciana Besedovsky,Tanja Lange,Monika Haack
Luciana Besedovsky
Sleep and immunity are bidirectionally linked. Immune system activation alters sleep, and sleep in turn affects the innate and adaptive arm of our body's defense system. Stimulation of the immune system by microbial challenges triggers an i...
Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases [0.03%]
内皮细胞向间充质细胞转化：在生理及人类疾病发病机制中的作用
Sonsoles Piera-Velazquez,Sergio A Jimenez
Sonsoles Piera-Velazquez
Numerous studies have demonstrated that endothelial cells are capable of undergoing endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular transdifferentiation. EndMT is a complex biological process in which endo...
The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian Reproduction [0.03%]
孤儿核受体甾族激素诱导蛋白-1和肝类固醇受体同源物-1：结构、调控及其在哺乳动物生殖中的重要作用
Marie-Charlotte Meinsohn,Olivia E Smith,Kalyne Bertolin et al.
Marie-Charlotte Meinsohn et al.
Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with classic nuclear receptor domain structure lacking identified signaling ligands are designated orphan nuclear receptors. Two of these, steroidogeni...
Pei Xiong Liew,Paul Kubes
Pei Xiong Liew
Neutrophils have always been considered as uncomplicated front-line troopers of the innate immune system equipped with limited proinflammatory duties. Yet recently, the role of the neutrophil has been undergoing a rejuvenation of sorts. Neu...
The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms [0.03%]
UDP-糖基转移酶(UGT)超家族：新成员、新功能和新模式
Robyn Meech,Dong Gui Hu,Ross A McKinnon et al.
Robyn Meech et al.
UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad range of exogenous chemicals and by-products of endoge...