John F Cryan,Kenneth J O&#x;Riordan,Caitlin S M Cowan et al.
John F Cryan et al.
The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regula...
Volker Vallon,Robert Unwin,Edward W Inscho et al.
Volker Vallon et al.
The understanding of the nucleotide/P2 receptor system in the regulation of renal hemodynamics and transport function has grown exponentially over the last 20 yr. This review attempts to integrate the available data while also identifying a...
Andrew R Chang,Christina M Ferrer,Raul Mostoslavsky
Andrew R Chang
Mammalian sirtuins have emerged in recent years as critical modulators of multiple biological processes, regulating cellular metabolism, DNA repair, gene expression, and mitochondrial biology. As such, they evolved to play key roles in orga...
Martin Hadamitzky,Laura Lückemann,Gustavo Pacheco-López et al.
Martin Hadamitzky et al.
The phenomenon of behaviorally conditioned immunological and neuroendocrine functions has been investigated for the past 100 yr. The observation that associative learning processes can modify peripheral immune functions was first reported a...
Metabolomics for Investigating Physiological and Pathophysiological Processes [0.03%]
代谢组学在探究生理和病理生理过程中的应用
David S Wishart
David S Wishart
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in metabolomics is leading to a renewed interest in metabol...
Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy [0.03%]
免疫、低氧和代谢——癌症的“三人行”：对肿瘤免疫治疗的启示
Carla Riera-Domingo,Annette Audigé,Sara Granja et al.
Carla Riera-Domingo et al.
It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment...
Tobias Moser,Chad P Grabner,Frank Schmitz
Tobias Moser
In recent years, sensory neuroscientists have made major efforts to dissect the structure and function of ribbon synapses which process sensory information in the eye and ear. This review aims to summarize our current understanding of two k...
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease [0.03%]
调控性细胞死亡的基本机制及其对心脏病的影响
Dominic P Del Re,Dulguun Amgalan,Andreas Linkermann et al.
Dominic P Del Re et al.
Twelve regulated cell death programs have been described. We review in detail the basic biology of nine including death receptor-mediated apoptosis, death receptor-mediated necrosis (necroptosis), mitochondrial-mediated apoptosis, mitochond...
Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue [0.03%]
肥胖、糖尿病和血压之间的机制联系：血管周围脂肪组织的作用
Sophie N Saxton,Ben J Clark,Sarah B Withers et al.
Sophie N Saxton et al.
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appea...
Cell Adhesion by Integrins [0.03%]
整合素介导的细胞黏附
Michael Bachmann,Sampo Kukkurainen,Vesa P Hytönen et al.
Michael Bachmann et al.
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in ...