Wei R Tan,David A Long,Luigi Gnudi
Wei R Tan
Nogo-B is an endoplasmic reticulum (ER) membrane-associated protein implicated in both physiological and pathological processes, particularly those that occur within blood vessels, highly vascularized tissues, and involve inflammatory and m...
Acid-sensing ion channels: structure, function, pharmacology and clinical significance [0.03%]
酸性敏感离子通道的结构、功能、药理及临床意义
Lachlan D Rash,Stephan Kellenberger
Lachlan D Rash
Changes in local proton concentrations within the body occur during synaptic transmission and metabolic activity and along the digestive tract. Perturbations to the strictly controlled physiological tissue pH are often associated with patho...
Patricia Silveyra,Maksat Babayev,Carolyn Damilola Ekpruke
Patricia Silveyra
Sex plays an essential role as a biological variable in lung health, leading to observed differences in lung disease susceptibility. Some respiratory conditions are more common in women than men, especially after puberty, indicating the inf...
Proglucagon-derived Peptides: Human Physiology and Therapeutic Potential [0.03%]
人胰高血糖素原衍生肽的生理作用和治疗潜力
Lærke S Gasbjerg,Casper K Nielsen,Malte P Suppli et al.
Lærke S Gasbjerg et al.
Proglucagon-derived peptides represent a class of peptide hormones derived from the proglucagon precursor. These peptides, including glucagon, glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2) and oxyntomodulin, exert diverse...
Yiming Peng-Winkler,Sarah-Maria Fendt
Yiming Peng-Winkler
Cancer cells reprogram their metabolism as they travel to distant organs to establish metastases, the leading cause of cancer-related mortality. While the metabolic state of primary tumors has been extensively studied, the specific metaboli...
Angiocrine and Pericrine Signaling: How Endothelial Cells and Pericytes Drive Cancer Progression and Therapy Resistance [0.03%]
血管内皮细胞和周细胞促进癌症进展与治疗抵抗的机制研究
Alexander M Jordan,Rebecca J G Drake,Kairbaan M Hodivala-Dilke
Alexander M Jordan
The emergence of treatment resistance and metastasis are significant challenges that need to be addressed to improve cancer patient outcomes. Greater insight into the mechanisms regulating these processes is needed to identify novel targets...
Sensing molecular carbon dioxide - a translational focus for respiratory disease [0.03%]
呼吸道疾病分子二氧化碳监测的临床转化研究
István Vadász,Eoin P Cummins,Deborah H Brotherton et al.
István Vadász et al.
The last two decades of research on carbon dioxide have demonstrated that CO2 is far more than a waste product of aerobic metabolism leading to acidosis, and that it elicits biological responses directly via non-pH-dependent molecular inter...
Gary C Sieck,Matthew J Fogarty
Gary C Sieck
In mammals, breathing requires an inspiratory pump to generate a negative intrathoracic pressure and thus pull air into the lungs for gas exchange. Exclusively in mammals, the diaphragm muscle (DIAm) is the major inspiratory pump, which sep...
Frontiers in the physiology of male pattern androgenetic alopecia: Beyond the androgen horizon [0.03%]
男性雄激素性脱发生理学研究的前沿：超越雄激素视野
Sabrina Altendorf,Marta Bertolini,Alizée Le Riche et al.
Sabrina Altendorf et al.
Male pattern androgenetic alopecia (mpAGA), the most common form of hair loss in men, represents a heritable, androgen-dependent complex trait distinct from female pattern hair loss. Despite the psychosocial burden of mpAGA in some affected...
Modan R Goldman,Mariel Molina-Castro,Jumar C Etkins et al.
Modan R Goldman et al.
Globally, alcohol is the most widely used psychoactive drug and a leading cause of premature death among individuals aged 15-49 years. Understanding the absorption, distribution, metabolism, and excretion of alcohol in the human body, other...