John E Schjenken,Sarah A Robertson
John E Schjenken
Seminal fluid is often assumed to have just one function in mammalian reproduction, delivering sperm to fertilize oocytes. But seminal fluid also transmits signaling agents that interact with female reproductive tissues to facilitate concep...
Connexins: Key Players in the Control of Vascular Plasticity and Function [0.03%]
缝隙连接蛋白：调控血管重塑与功能的重要因子
Ulrich Pohl
Ulrich Pohl
Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically regulated degree. Full-length connexins oligomerize and for...
Are We Meeting the Promise of Endotypes and Precision Medicine in Asthma? [0.03%]
哮喘领域基于内型的精准医学现状如何？
Anuradha Ray,Matthew Camiolo,Anne Fitzpatrick et al.
Anuradha Ray et al.
While the term asthma has long been known to describe heterogeneous groupings of patients, only recently have data evolved which enable a molecular understanding of the clinical differences. The evolution of transcriptomics (and other 'omic...
Ferda Cevikbas,Ethan A Lerner
Ferda Cevikbas
Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly understood and appreciated. The pathophysiological consequences of itch impact quality of life as much as pain. These dynamics have led to increa...
Laura M J Fernandez,Anita Lüthi
Laura M J Fernandez
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As one of the most inheritable sleep EEG signatures, sleep spindl...
Regulation of the Renal NaCl Cotransporter and Its Role in Potassium Homeostasis [0.03%]
肾NaCl共转运体的调节及其在钾平衡中的作用
Ewout J Hoorn,Martin Gritter,Catherina A Cuevas et al.
Ewout J Hoorn et al.
Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is achieved by translocating K+ into cells and increasing uri...
mRNA Metabolism in Cardiac Development and Disease: Life After Transcription [0.03%]
心脏发育和疾病中的mRNA代谢：转录之后的生命
Chen Gao,Yibin Wang
Chen Gao
The central dogma of molecular biology illustrates the importance of mRNAs as critical mediators between genetic information encoded at the DNA level and proteomes/metabolomes that determine the diverse functional outcome at the cellular an...
Muscle Toxicity of Drugs: When Drugs Turn Physiology into Pathophysiology [0.03%]
药物的肌肉毒性：当药物将生理变为病理生理学时发生的肌肉毒性反应
Lando Janssen,Neeltje A E Allard,Christiaan G J Saris et al.
Lando Janssen et al.
Drugs are prescribed to manage or prevent symptoms and diseases, but may sometimes cause unexpected toxicity to muscles. The symptomatology and clinical manifestations of the myotoxic reaction can vary significantly between drugs and betwee...
Paul A Janmey,Daniel A Fletcher,Cynthia A Reinhart-King
Paul A Janmey
Physical stimuli are essential for the function of eukaryotic cells, and changes in physical signals are important elements in normal tissue development as well as in disease initiation and progression. The complexity of physical stimuli an...
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease [0.03%]
瞬时受体电位锚蛋白1通道：从结构到疾病
Karel Talavera,Justyna B Startek,Julio Alvarez-Collazo et al.
Karel Talavera et al.
The transient receptor potential ankyrin (TRPA) channels are Ca2+-permeable nonselective cation channels remarkably conserved through the animal kingdom. Mammals have only one member, TRPA1, which is widely expressed in sensory neurons and ...