Giulia Biffi,David A Tuveson
Giulia Biffi
Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite the presence of non-neoplastic stromal components that substantially contribute to the progression of the tumor. Indeed, cancer c...
Andrew B Barker,Brant M Wagener
Andrew B Barker
Molecular Physiology and Pathophysiology of Bilirubin Handling by the Blood, Liver, Intestine, and Brain in the Newborn [0.03%]
新生儿血液、肝脏、肠道和脑内胆红素代谢的分子生理学和病理生理学
Thor W R Hansen,Ronald J Wong,David K Stevenson
Thor W R Hansen
Bilirubin is the end product of heme catabolism formed during a process that involves oxidation-reduction reactions and conserves iron body stores. Unconjugated hyperbilirubinemia is common in newborn infants, but rare later in life. The ba...
Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm [0.03%]
心脏机械电偶联：力学刺激对心率和心律的急性影响
T Alexander Quinn,Peter Kohl
T Alexander Quinn
The heart is vital for biological function in almost all chordates, including humans. It beats continually throughout our life, supplying the body with oxygen and nutrients while removing waste products. If it stops, so does life. The heart...
Nati Hernando,Kenneth Gagnon,Eleanor Lederer
Nati Hernando
Phosphate is an essential nutrient for life and is a critical component of bone formation, a major signaling molecule, and structural component of cell walls. Phosphate is also a component of high-energy compounds (i.e., AMP, ADP, and ATP) ...
Susan M Wall,Jill W Verlander,Cesar A Romero
Susan M Wall
Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the three IC subtypes identified, type B intercalated cells are one of the best characterized and known to mediate Cl- absorption and HCO3- secretion, l...
Christian Giaume,Christian C Naus,Juan C Sáez et al.
Christian Giaume et al.
Over the past several decades a large amount of data have established that glial cells, the main cell population in the brain, dynamically interact with neurons and thus impact their activity and survival. One typical feature of glia is the...
Roberto Papait,Simone Serio,Gianluigi Condorelli
Roberto Papait
Gene expression is needed for the maintenance of heart function under normal conditions and in response to stress. Each cell type of the heart has a specific program controlling transcription. Different types of stress induce modifications ...
Elisabeth Hessmann,Soeren M Buchholz,Ihsan Ekin Demir et al.
Elisabeth Hessmann et al.
Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment (TME) that dynamically evolves during tumor progression. The TME con...
Onur Güntürkün,Felix Ströckens,Sebastian Ocklenburg
Onur Güntürkün
Comparative studies on brain asymmetry date back to the 19th century but then largely disappeared due to the assumption that lateralization is uniquely human. Since the reemergence of this field in the 1970s, we learned that left-right diff...