Role of O-Linked N-Acetylglucosamine Protein Modification in Cellular (Patho)Physiology [0.03%]
O连接的N-乙酰葡萄糖胺蛋白修饰在细胞（病理）生理中的作用
John C Chatham,Jianhua Zhang,Adam R Wende
John C Chatham
In the mid-1980s, the identification of serine and threonine residues on nuclear and cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O-linkage overturned the widely held assumption that glycosylation only occ...
A Sica,M P Colombo,A Trama et al.
A Sica et al.
Cancer patients appear to be more likely to be diagnosed with coronavirus disease 2019 (COVID-19). This is supported by the understanding of immunometabolic pathways that intersect patients with infection and cancer. However, data derived b...
Hui-Ming Chang,Edward T H Yeh
Hui-Ming Chang
Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates multiple biological processes, including cell division, DNA replication/repair, signal transduction, and cellular metabolism. In this review, we wil...
Haruhiko Ogawa,Hidesaku Asakura
Haruhiko Ogawa
Paul J Davis,Shaker A Mousa,Hung-Yun Lin
Paul J Davis
The extracellular domain of plasma membrane integrin αvβ3 contains a cell surface receptor for thyroid hormone analogues. The receptor is largely expressed and activated in tumor cells and rapidly dividing endothelial cells. The principal...
Nanna Brix Finnerup,Rohini Kuner,Troels Staehelin Jensen
Nanna Brix Finnerup
Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition with major impact on quality of life. Examples include trigeminal neuralgia, painful polyneuropathy, postherpetic neuralgi...
CRISPR Tools for Physiology and Cell State Changes: Potential of Transcriptional Engineering and Epigenome Editing [0.03%]
生理与细胞状态改变的CRISPR工具—— transcriptional工程和表观基因组编辑的应用潜力
Christopher T Breunig,Anna Köferle,Andrea M Neuner et al.
Christopher T Breunig et al.
Given the large amount of genome-wide data that have been collected during the last decades, a good understanding of how and why cells change during development, homeostasis, and disease might be expected. Unfortunately, the opposite is tru...
Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain [0.03%]
大脑中的细胞回路及其在急性疼痛和慢性疼痛中的调节作用
Rohini Kuner,Thomas Kuner
Rohini Kuner
Chronic, pathological pain remains a global health problem and a challenge to basic and clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been that the nature of neural circuits underlying the divers...
Stefano Romagnoli,Adriano Peris,A Raffaele De Gaudio et al.
Stefano Romagnoli et al.
First isolated in China in early 2020, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the novel coronavirus responsible for the ongoing pandemic of Coronavirus Disease 2019 (COVID-19). The disease has been spreading rapidly...