Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior [0.03%]
心脏跨膜离子通道和动作电位：细胞生理与心律失常行为
András Varró,Jakub Tomek,Norbert Nagy et al.
András Varró et al.
Cardiac arrhythmias are among the leading causes of mortality. They often arise from alterations in the electrophysiological properties of cardiac cells and their underlying ionic mechanisms. It is therefore critical to further unravel the ...
Expression and Function of the Epidermal Growth Factor Receptor in Physiology and Disease [0.03%]
表皮生长因子受体在生理和疾病中的表达与功能
Jianchun Chen,Fenghua Zeng,Steven J Forrester et al.
Jianchun Chen et al.
The epidermal growth factor receptor (EGFR) is the prototypical member of a family of membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated by multiple ligands, including EGF, transforming growth factor...
Rico Schieweck,Jovica Ninkovic,Michael A Kiebler
Rico Schieweck
Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA decay provides an important regulatory layer in many if not all molecular pathways. Research in the last decades has positioned RNA-binding proteins...
BEHAVIORAL AND NEUROBIOLOGICAL MECHANISMS OF PAVLOVIAN AND INSTRUMENTAL EXTINCTION LEARNING [0.03%]
巴甫洛夫式和工具性消退学习的行为及神经生物学机制
Mark E Bouton,Stephen Maren,Gavan P McNally
Mark E Bouton
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a behavior that has been acquired through Pavlovian or instrumental (operant) learning decreases in strength when the outcome that reinforced it is remo...
Elizabeth A N Wastnedge,Rebecca M Reynolds,Sara R van Boeckel et al.
Elizabeth A N Wastnedge et al.
There are many unknowns for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. Clinical experience of pregnancies complicated with infection by other coronaviruses e.g., Severe Acute Respiratory Syndrome (SARS) and Midd...
Jochen F Staiger,Carl C H Petersen
Jochen F Staiger
The array of whiskers on the snout provides rodents with tactile sensory information relating to the size, shape and texture of objects in their immediate environment. Rodents can use their whiskers to detect stimuli, distinguish textures, ...
Kayla F Goliwas,Jessy S Deshane,Craig A Elmets et al.
Kayla F Goliwas et al.
The host immune system shapes the fate of tumor progression. Hence, manipulating patients' immune system to activate host immune responses against cancer pathogenesis is a promising strategy to develop effective therapeutic interventions fo...
Molecular Physiology of Bile Acid Signaling in Health, Disease, and Aging [0.03%]
胆酸信号的分子生理学在健康，疾病和衰老中的作用
Alessia Perino,Hadrien Demagny,Laura Velazquez-Villegas et al.
Alessia Perino et al.
Over the past two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by ...
Brain mechanisms of insomnia: new perspectives on causes and consequences [0.03%]
失眠症的脑机制：对病因和后果的新认识
Eus J W Van Someren
Eus J W Van Someren
While insomnia is the second most common mental disorder, progress in our understanding of underlying neurobiological mechanisms has been limited. The present review addresses the definition and prevalence of insomnia and explores its subje...
The FGF/FGFR system in the physiopathology of the prostate gland [0.03%]
成纤维细胞生长因子/成纤维细胞生长因子受体系统在前列腺生理病理中的作用
Arianna Giacomini,Elisabetta Grillo,Sara Rezzola et al.
Arianna Giacomini et al.
Fibroblast growth factors (FGFs) are a family of proteins possessing paracrine, autocrine, or endocrine functions in a variety of biological processes, including embryonic development, angiogenesis, tissue homeostasis, wound repair, and can...