Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedema [0.03%]
淋巴系统的发育和生理功能：来自原发性淋巴水肿的人类遗传研究的新见解
Silvia Martin-Almedina,Peter S Mortimer,Pia Ostergaard
Silvia Martin-Almedina
Primary lymphedema is a long-term (chronic) condition characterized by tissue lymph retention and swelling that can affect any part of the body, although it usually develops in the arms or legs. Due to the relevant contribution of the lymph...
Camilla Ferrari,Sandro Sorbi
Camilla Ferrari
The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end of the century to identify the components of pathological hallmarks and genetic subtypes and to formulate the first pathogenic hypothesis. Thanks t...
Sadis Matalon,Carol Ann Remme,Willis K Samson
Sadis Matalon
Lipodistrophy: a paradigm for understanding the consequences of "overloading" adipose tissue [0.03%]
脂营养不良：“过载”脂肪组织后果的研究范例
Koini Lim,Afreen Haider,Claire Adams et al.
Koini Lim et al.
Lipodystrophies have been recognized since at least the nineteenth century and, despite their rarity, tended to attract considerable medical attention because of the severity and somewhat paradoxical nature of the associated metabolic disea...
Philippe Clézardin,Rob Coleman,Margherita Puppo et al.
Philippe Clézardin et al.
Skeletal metastases are frequent complications of many cancers, causing bone complications (fractures, bone pain, disability) that negatively affect the patient's quality of life. Here, we first discuss the burden of skeletal complications ...
G protein-coupled receptor-G protein interactions: a single-molecule perspective [0.03%]
从单分子角度研究G蛋白偶联受体与G蛋白的相互作用
Davide Calebiro,Zsombor Koszegi,Yann Lanoiselée et al.
Davide Calebiro et al.
G protein-coupled receptors (GPCRs) regulate many cellular and physiological processes, responding to a diverse range of extracellular stimuli including hormones, neurotransmitters, odorants, and light. Decades of biochemical and pharmacolo...
Daniel J Hoffman,Theresa L Powell,Emily S Barrett et al.
Daniel J Hoffman et al.
Almost 2 billion adults in the world are overweight, and more than half of them are classified as obese, while nearly one-third of children globally experience poor growth and development. Given the vast amount of knowledge that has been gl...
Christian Aalkjær,Holger Nilsson,Jo G R De Mey
Christian Aalkjær
Small arteries, which play important roles in controlling blood flow, blood pressure, and capillary pressure, are under nervous influence. Their innervation is predominantly sympathetic and sensory motor in nature, and while some arteries a...
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species [0.03%]
脊椎动物性别决定、性腺分化及可塑性研究进展
Yoshitaka Nagahama,Tapas Chakraborty,Bindhu Paul-Prasanth et al.
Yoshitaka Nagahama et al.
A diverse array of sex determination (SD) mechanisms, encompassing environmental to genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD mechanisms (mammals) to functional sex change in fishes (sequential h...
Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets [0.03%]
COVID-19病理生理中的炎症和血栓形成：蛋白酶激活受体和嘌呤能受体作为驱动因素和潜在治疗靶点
Krishna Sriram,Paul A Insel
Krishna Sriram
Evolving information has identified disease mechanisms and dysregulation of host biology that might be targeted therapeutically in coronavirus disease 2019 (COVID-19). Thrombosis and coagulopathy, associated with pulmonary injury and inflam...