Peng Tan,Lian He,Yun Huang et al.
Peng Tan et al.
Optogenetics combines light and genetics to enable precise control of living cells, tissues, and organisms with tailored functions. Optogenetics has the advantages of noninvasiveness, rapid responsiveness, tunable reversibility, and superio...
Stephan E Lehnart,Xander H T Wehrens
Stephan E Lehnart
Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR). Tethering of these membrane structures results in the formation of h...
David B Hill,Brian Button,Michael Rubinstein et al.
David B Hill et al.
The mucus clearance system is the dominant mechanical host defense system of the human lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid pumping and cough-dependent mechanisms, and mucus transpor...
Mechanisms and physiological implications of cooperative gating of clustered ion channels [0.03%]
集群离子通道合作 gate 的机制及其生理意义
Rose E Dixon,Manuel F Navedo,Marc D Binder et al.
Rose E Dixon et al.
Ion channels play a central role in the regulation of nearly every cellular process. Dating back to the classic 1952 Hodgkin-Huxley model of the generation of the action potential, ion channels have always been thought of as independent age...
The evolution of regulated cell death pathways in animals and their evasion by pathogens [0.03%]
动物受调控细胞死亡通路的进化及其被病原物的逃避策略
Bart Tummers,Douglas R Green
Bart Tummers
The coevolution of host-pathogen interactions underlies many human physiological traits associated with protection from or susceptibility to infections. Among the mechanisms that animals utilize to control infections are the regulated cell ...
Heterogeneity of glutamatergic synapses: cellular mechanisms and network consequences [0.03%]
谷氨酸能突触的异质性：细胞机制和网络影响
Carolin Wichmann,Thomas Kuner
Carolin Wichmann
Chemical synapses are commonly known as a structurally and functionally highly diverse class of cell-cell contacts specialized to mediate communication between neurons. They represent the smallest "computational" unit of the brain and are t...
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms [0.03%]
哺乳动物跨膜腺苷酸环化酶异构体的生理作用
Katrina F Ostrom,Justin E LaVigne,Tarsis F Brust et al.
Katrina F Ostrom et al.
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1-9, that serve as major effector enzymes of G protein-coupled receptors (GPCRs). T...
Georgios Kararigas
Georgios Kararigas
Joanne F Garbincius,John W Elrod
Joanne F Garbincius
The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a fundamental biological process that has critical effects on cellular metabolism, signaling, and survival. Disruption of mitochondrial calcium (mCa2+) cyc...
A comprehensive review of the neuroscience of ingestion: the physiological control of eating: signals, neurons, and networks [0.03%]
进食神经科学的全面回顾：进食的生理控制：信号，神经元和网络
Willis K Samson,Gina L C Yosten
Willis K Samson