Ben D B Willmore,Andrew J King
Ben D B Willmore
Adaptation is an essential feature of auditory neurons, which reduces their responses to unchanging and recurring sounds and allows their response properties to be matched to the constantly changing statistics of sounds that reach the ears....
Alexander Staruschenko,Rong Ma,Oleg Palygin et al.
Alexander Staruschenko et al.
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to the renal tubules for subsequent processing. This process, known as glomerular filtration, is controlled by intrinsic regulatory systems and ...
Spencer A Freeman,Sergio Grinstein,John Orlowski
Spencer A Freeman
The protonation state of soluble and membrane-associated macromolecules dictates their charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) partake in numerous metabolic reactions and serve as a sour...
Jorge Domínguez-Andrés,Jéssica Cristina Dos Santos,Siroon Bekkering et al.
Jorge Domínguez-Andrés et al.
The mechanisms underlying innate immune memory have been extensively explored in the last decades but are in fact largely unknown. Although the specificity of adaptive immune memory in vertebrates is ensured through the recombination of imm...
Natalie R Harris,László Bálint,Danielle M Dy et al.
Natalie R Harris et al.
The heart is imbued with a vast lymphatic network that is responsible for fluid homeostasis and immune cell trafficking. Disturbances in the forces that regulate microvascular fluid movement can result in myocardial edema, which has profibr...
Neutrophil extracellular traps in the pathology of cancer and other inflammatory diseases [0.03%]
中性粒细胞胞外陷阱在癌症及其他炎症性疾病病理中的作用
Melanie Herre,Jessica Cedervall,Nigel Mackman et al.
Melanie Herre et al.
Neutrophil extracellular trap (NET) formation, first described in 2004 as a previously unknown strategy of neutrophils to fight microbes, has attracted an increasing interest in the research community. NETs are formed when neutrophils exter...
Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum [0.03%]
发育性和癫痫性脑病：从遗传异质性到表型连续谱
Renzo Guerrini,Valerio Conti,Massimo Mantegazza et al.
Renzo Guerrini et al.
Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of disorders characterized by early-onset, often severe epileptic seizures and EEG abnormalities on a background of developmental impairment that tends to worsen ...
Ronald J A Wanders,Myriam Baes,Daniela Ribeiro et al.
Ronald J A Wanders et al.
Peroxisomes are subcellular organelles that play a central role in human physiology by catalyzing a range of unique metabolic functions. The importance of peroxisomes for human health is exemplified by the existence of a group of usually se...
Chloe J Peach,Laura E Edgington-Mitchell,Nigel W Bunnett et al.
Chloe J Peach et al.
Proteases are signaling molecules that specifically control cellular functions by cleaving protease-activated receptors (PARs). The four known PARs are members of the large family of G protein-coupled receptors. These transmembrane receptor...
Max C Petersen,Molly R Gallop,Stephany Flores Ramos et al.
Max C Petersen et al.
Time-restricted eating (TRE) is a dietary intervention that limits food consumption to a specific time window each day. The effect of TRE on body weight and physiological functions has been extensively studied in rodent models, which have s...