Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training [0.03%]
急性运动的分子反应及其对运动训练适应性的影响中的相关性
Brendan Egan,Adam P Sharples
Brendan Egan
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured exercise training are a potent stimulus for physiological adaptation in many organs. Specifically, in skeletal muscle, remarkable plasticity is demo...
Windows into stress: a glimpse at emerging roles for CRHPVN neurons [0.03%]
压力的窗口：对新兴的CRHPVN神经元作用的一瞥
Neilen P Rasiah,Spencer P Loewen,Jaideep S Bains
Neilen P Rasiah
The corticotropin-releasing hormone cells in the paraventricular nucleus of the hypothalamus (CRHPVN) control the slow endocrine response to stress. The synapses on these cells are exquisitely sensitive to acute stress, leveraging local sig...
Jessica C Pressey,Miranda de Saint-Rome,Vineeth A Raveendran et al.
Jessica C Pressey et al.
Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the foundation of nervous system function. This inhibition is largely mediated by the neurotransmitters GABA and glycine that activate Cl--permeable ion ...
Multisystem physiological perspective of human frailty and its modulation by physical activity [0.03%]
多系统生理脆弱性理论及其运动干预机制研究进展
Joseph A Taylor,Paul L Greenhaff,David B Bartlett et al.
Joseph A Taylor et al.
"Frailty" is a term used to refer to a state characterized by enhanced vulnerability to, and impaired recovery from, stressors compared with a nonfrail state, which is increasingly viewed as a loss of resilience. With increasing life expect...
Contribution of adaptive immunity to human COPD and experimental models of emphysema [0.03%]
适应性免疫在人类慢性阻塞性肺疾病和肺气肿实验模型中的作用贡献
Farrah Kheradmand,Yun Zhang,David B Corry
Farrah Kheradmand
The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed role of innate immune cells in this condition have dominated the field in the basic research arena for many years. Recently, however, compelling data sug...
The choroid plexus: a missing link in our understanding of brain development and function [0.03%]
脉络膜丛：在我们对大脑发育和功能理解中的缺失环节
Norman R Saunders,Katarzyna M Dziegielewska,Ryann M Fame et al.
Norman R Saunders et al.
Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier, despite a much longer history. This review has two overall aims. The first is to outline long-standing areas of research where there are unanswered...
Megan A Evans,Kenneth Walsh
Megan A Evans
Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the same tissue, is an evitable consequence of human aging. The hematopoietic system is no exception to this, where studies have revealed the presence of ...
Cellular senescence and cardiovascular diseases: moving to the "heart" of the problem [0.03%]
细胞衰老与心血管疾病：迈向问题的核心
Konstantinos Evangelou,Panagiotis V S Vasileiou,Angelos Papaspyropoulos et al.
Konstantinos Evangelou et al.
Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an immense impact on patient quality of life and disability. Clinical evidence has revealed a strong connection between cellular senescence and worse cardia...
John P A Ioannidis
John P A Ioannidis