Sympathetic circuits regulating hepatic glucose metabolism: where we stand [0.03%]
肝糖代谢的交感神经调节通路：研究现状
Andrea Zsombok,Lucie D Desmoulins,Andrei V Derbenev
Andrea Zsombok
The prevalence of metabolic disorders, including type 2 diabetes mellitus, continues to increase worldwide. Although newer and more advanced therapies are available, current treatments are still inadequate and the search for solutions remai...
The conducted vasomotor response and the principles of electrical communication in resistance arteries [0.03%]
灌注介导的血管运动反应及阻力动脉电通讯原理
Galina Yu Mironova,Paulina M Kowalewska,Mohammed El-Lakany et al.
Galina Yu Mironova et al.
Biological tissues are fed by arterial networks whose task is to set blood flow delivery in accordance with energetic demand. Coordinating vasomotor activity among hundreds of neighboring segments is an essential process, one dependent upon...
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions [0.03%]
机械过载诱导骨骼肌肥大的机制研究：现状和未来方向
Michael D Roberts,John J McCarthy,Troy A Hornberger et al.
Michael D Roberts et al.
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have been extensively researched since the landmark report by Morpurgo (1897) of "work-induced hypertrophy" in dogs that were treadmill trained. Much of the precl...
Tatsuya Tsukahara,David H Brann,Sandeep Robert Datta
Tatsuya Tsukahara
Anosmia, the loss of the sense of smell, is one of the main neurological manifestations of COVID-19. Although the SARS-CoV-2 virus targets the nasal olfactory epithelium, current evidence suggests that neuronal infection is extremely rare i...
David Eisner,Erwin Neher,Holger Taschenberger et al.
David Eisner et al.
Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is bound to buffers, with typically only ∼1% being freely ionized at resting levels in most cells. Physiological Ca2+ buffers include small molecules and ...
Ana J Pinto,Audrey Bergouignan,Paddy C Dempsey et al.
Ana J Pinto et al.
Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or reclining posture. Evidence relevant to understanding the physiology of SB can be derived from studies employing several experimental models: bed res...
Climate change impacts on respiratory health: exposure, vulnerability, and risk [0.03%]
气候变化对呼吸健康的影响：暴露、脆弱性和风险
Hannah H Covert,Firoz Abdoel Wahid,Sally E Wenzel et al.
Hannah H Covert et al.
Anthropogenic climate change adversely impacts human health. In this perspective, we examine the impact of climate change on respiratory health risk. We describe five respiratory health threats-heat, wildfires, pollen, extreme weather event...
Roger A Nicoll,Howard Schulman
Roger A Nicoll
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP) were discovered within a decade of each other and have been inextricably intertwined ever since. However, like many marriages, it has had its up and downs...
The placenta: epigenetic insights into trophoblast developmental models of a generation-bridging organ with long-lasting impact on lifelong health [0.03%]
胎盘：表观遗传学见解——生成跨越一代的器官及其对终生健康影响的胎盘发育模型
Myriam Hemberger,Wendy Dean
Myriam Hemberger
The placenta is a unique organ system that functionally combines both maternal and fetal cell types with distinct lineage origins. Normal placentation is critical for developmental progression and reproductive success. Although the placenta...
Evelyn E Telfer,Johanne Grosbois,Yvonne L Odey et al.
Evelyn E Telfer et al.
Mammalian eggs (oocytes) are formed during fetal life and establish associations with somatic cells to form primordial follicles that create a store of germ cells (the primordial pool). The size of this pool is influenced by key events duri...