Qin Fu,Ying Wang,Chen Yan et al.
Qin Fu et al.
Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Both cyclic nucleotides are critical secondary messengers i...
Brooke R Shepley,Anthony R Bain
Brooke R Shepley
CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease [0.03%]
CD36在心肌脂代谢中的守门人作用及其在代谢性疾病治疗中的靶点作用
Jan F C Glatz,Lisa C Heather,Joost J F P Luiken
Jan F C Glatz
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 facilitates the cellular uptake of long-chain fatty aci...
Orrin Devinsky,Nicholas A Jones,Mark O Cunningham et al.
Orrin Devinsky et al.
Cannabis has been used to treat convulsions and other disorders since ancient times. In the last few decades, preclinical animal studies and clinical investigations have established the role of cannabidiol (CBD) in treating epilepsy and sei...
Alain R Thierry
Alain R Thierry
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease [0.03%]
氧化应激与神经退行性疾病：阿尔茨海默病发病与进展中的作用机制研究
Marzia Perluigi,Fabio Di Domenico,D Allan Butterfield
Marzia Perluigi
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms, among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises in various pathways regulating brain functions, and it seem...
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries [0.03%]
糖皮质激素的作用、性别二态性及与疾病的关系：新概念、机制和发现
Genesee J Martinez,Malik Appleton,Zachary A Kipp et al.
Genesee J Martinez et al.
The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential c...
Hussam El-Nashar,Malak Sabry,Yuan-Tsan Tseng et al.
Hussam El-Nashar et al.
While studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across t...
Tissue transglutaminase: a multifunctional and multisite regulator in health and disease [0.03%]
组织.transglutaminase：健康和疾病中的多功能及多部位调节因子
Zhouzhou Yao,Yuhua Fan,Lizhen Lin et al.
Zhouzhou Yao et al.
Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a broad range of cellular and metabolic functions carried out in a variety of cellular compartments. In addition to transamidation, TG2 also functions...