Relationship between repertoire diversity of B cell receptor immunoglobulin G heavy chain and infectious complications caused by encapsulated bacteria after allogeneic hematopoietic cell transplantation [0.03%]
同种异基因造血干细胞移植后包裹细菌感染并发症与B细胞受体免疫球蛋白G重链组库多样性之间的关系
Shun-Ichi Kimura,Kazuaki Kameda,Hideki Nakasone et al.
Shun-Ichi Kimura et al.
Background: We evaluated the relationship between repertoire diversity of IgG-BCR heavy chain and encapsulated bacterial infections after allogeneic hematopoietic cell transplantation. ...
Efficacy and safety of telitacicept for myasthenia gravis in real-world practice and exploratory outcomes in the elderly subgroup [0.03%]
替拉西特治疗重症肌无力真实世界疗效和安全性及老年亚组探索性结果分析
Xiang Xiao,Qiuming Zeng,Song Ouyang et al.
Xiang Xiao et al.
Objective: To assess the efficacy and safety of telitacicept in myasthenia gravis (MG), focusing on elderly patients. Methods: Sixteen ...
Development and persistence of memory immune recall response following SARS-CoV-2 infection in children [0.03%]
儿童新冠病毒感染后免疫记忆再激活反应的建立与维持
Youmna El-Orfali,Rana Mansour,Habib AlKalamouni et al.
Youmna El-Orfali et al.
SARS-CoV-2 infection is generally mild in children, yet the magnitude and durability of post-infection immune memory remain poorly defined. In this longitudinal study, humoral and cellular immune responses were comprehensively analyzed in 1...
ADAM9 supports regulatory T cell stability through TGF-β-SMAD signaling and is reduced in systemic lupus erythematosus [0.03%]
ADAM9通过TGF-β-SMAD信号传导支持调节性T细胞稳定性并在系统性红斑狼疮中减少表达
Theodoros Vichos,Wei Li,Kohei Karino et al.
Theodoros Vichos et al.
Background: A Disintegrin and Metalloproteinase 9 (ADAM9) has been implicated in Th17 cell differentiation by activating TGF-β. Given the essential role of TGF-β in maintaining regulatory T (Treg) cell lineage, we hypot...
Identification of a novel hypomorphic variant in CYBB underlying an adult presentation of X-linked recessive Mendelian susceptibility to mycobacterial disease [0.03%]
一种新型低效应变异体CYBB的鉴定在X染色体连锁的成人分枝杆菌疾病易感性中的作用
Willem Roosens,Marjon Wouters,Frederik Staels et al.
Willem Roosens et al.
Deleterious mutations in the CYBB gene encoding NOX2 typically cause X-linked recessive chronic granulomatous disease (XR-CGD) by affecting NADPH oxidase-dependent respiratory burst in phagocytes. However, two missense variants (T178P, Q231...
The MENAT Region Inborn Errors of Immunity Research Consortium Registry (MENAT-IEI-RCR): Establishing a regional framework for collaborative research [0.03%]
中东和北非地区先天性免疫缺陷研究联盟注册中心(MENAT-IEI-RCR)：建立区域协作研究框架
Mohamed-Ridha Barbouche,Waleed Al-Herz,Mohammed Yousuf Karim et al.
Mohamed-Ridha Barbouche et al.
Effect of dynamics and timing of SARS-CoV-2 vaccination on immune response in people with multiple sclerosis during cladribine treatment [0.03%]
SARS-CoV-2疫苗接种的动力学和时机对克拉屈滨治疗的多发性硬化症患者免疫反应的影响
Claudia Russo,Clorinda Fusco,Fortunata Carbone et al.
Claudia Russo et al.
Since the onset of the COVID-19 pandemic, the World Health Organization has recommended vaccination for people with multiple sclerosis (pwMS). However, vaccine-induced immune responses in pwMS receiving immunomodulatory therapies are curren...
Pre- and peri-hematopoietic cell transplant management of disseminated non-Helicobacter pylori Helicobacter infection in X-linked agammaglobulinemia: Case series and literature review [0.03%]
X连锁低丙球血症患者播散性非幽门螺杆菌Helicobacter感染的移植前和移植期管理：病例系列及文献回顾
Rachel Lee,Danielle E Arnold,Mark Parta et al.
Rachel Lee et al.
Non-Helicobacter pylori Helicobacter (NHPH) species are recognized as a cause of chronic systemic infection, cellulitis, and osteomyelitis in patients with X-linked agammaglobulinemia (XLA). Diagnosis and treatment are challenging due to fa...
Polymorphonuclear myeloid-derived suppressor cells inhibit natural killer cell function in neuromyelitis optica spectrum disorder via the CD155-TIGIT axis [0.03%]
多形核髓系来源的抑制细胞通过CD155-TIGIT轴抑制视神经脊髓炎谱系障碍中的自然杀伤细胞功能
Chao Zhang,Zonghao Pan,Xuli Ma et al.
Chao Zhang et al.
Natural killer (NK) cells and myeloid-derived suppressor cells (MDSCs) are implicated in neuromyelitis optica spectrum disorder (NMOSD), but their potential interplay remains unclear. In this study, we identified an increased frequency of p...
Decorin as a dynamic regulator in fibrosis: Mechanisms, therapeutic potential and future challenges [0.03%]
decorin在纤维化中的动态调节作用：机制、治疗潜力及未来挑战
Wenqian Zhang,Shaozhe Cai,Jiayi Ma et al.
Wenqian Zhang et al.
Fibrosis is a pathological process commonly encountered in patients with rheumatic diseases, infections and other related conditions. Due to the lack of effective therapeutic strategies, it has been associated with up to 45% of deaths in in...