Rebecca Allison,Asha Guraka,Isaac Thom Shawa et al.
Rebecca Allison et al.
Drug-Induced Liver Injury (DILI) constitutes hepatic damage attributed to drug exposure. DILI may be categorized as hepatocellular, cholestatic or mixed and might also involve immune responses. When DILI occurs in dose-dependent manner, it ...
Buthionine sulfoximine and chemoresistance in cancer treatments: a systematic review with meta-analysis of preclinical studies [0.03%]
硫氧胱胺与癌症化疗耐药：基于前期研究的系统性回顾和元分析
Camila Dos Reis Oliveira,Joedna Cavalcante Pereira,Andressa Barros Ibiapina et al.
Camila Dos Reis Oliveira et al.
Buthionine sulfoximine (BSO) is a synthetic amino acid that blocks the biosynthesis of reduced glutathione (GSH), an endogenous antioxidant cellular component present in tumor cells. GSH levels have been associated with tumor cell resistanc...
Continent-based systematic review of the short-term health impacts of wildfire emissions [0.03%]
基于大陆的野火排放短期健康影响系统评价
Bela Barros,Marta Oliveira,Simone Morais
Bela Barros
This review systematically gathers and provides an analysis of pollutants levels emitted from wildfire (WF) and their impact on short-term health effects of affected populations. The available literature was searched according to Population...
Effects of green tea polyphenols against metal-induced genotoxic damage: underlying mechanistic pathways [0.03%]
绿茶多酚对金属染毒所致遗传毒性损伤的影响及作用机制研究
María Del Carmen García-Rodríguez,Lourdes Montserrat Hernández-Cortés,Víctor Manuel Mendoza-Núñez et al.
María Del Carmen García-Rodríguez et al.
This review is based upon evidence from the published effects of green tea polyphenols (GTP) on genotoxic damage induced by metals with carcinogenic potential. First, the relationship between GTP and antioxidant defense system is provided. ...
Samuel M Cohen,Christopher Bevan,Bhaskar Gollapudi et al.
Samuel M Cohen et al.
Carbon tetrachloride (CCl4) has been extensively used and reported to produce toxicity, most notably involving the liver. Carbon tetrachloride metabolism involves CYP450-mediated bioactivation to trichloromethyl and trichloromethyl peroxy r...
Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays [0.03%]
三氯半乳糖蔗糖酯及其母体甜味剂的毒理学和药代动力学性质：体内筛选试验
Susan S Schiffman,Elizabeth H Scholl,Terrence S Furey et al.
Susan S Schiffman et al.
The purpose of this study was to determine the toxicological and pharmacokinetic properties of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6-acetate is an intermediate and impurity in the manufa...
Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD) [0.03%]
烟草烟雾诱发的慢性阻塞性肺疾病的动物模型及机制研究
Priya Upadhyay,Ching-Wen Wu,Alexa Pham et al.
Priya Upadhyay et al.
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, and its global health burden is increasing. COPD is characterized by emphysema, mucus hypersecretion, and persistent lung inflammation, and clinical...
Drug development, Brazilian biodiversity and political choices: Where are we heading? [0.03%]
药物研发、巴西生物多样性和政治选择：我们何去何从？
Paulo Michel Pinheiro Ferreira,Daniel Dias Rufino Arcanjo,Ana Paula Peron
Paulo Michel Pinheiro Ferreira
The aim of this review was to (i) acknowledge structural advantages of natural products (NPs) for designing therapeutic drugs; (ii) emphasize how wildlife conservation is socially and economically necessary for scientific and commercial pro...
In vitro data for fire pollutants: contribution of studies using human cell models towards firefighters' occupational [0.03%]
体外数据用于火灾污染物：使用人类细胞模型的研究对消防人员职业暴露的贡献
Maria João Bessa,Bruno Sarmento,Marta Oliveira et al.
Maria João Bessa et al.
Firefighters are the principal line of defense against fires, being at elevated risk of exposure to health-relevant pollutants released during fires and burning processes. Although many biomonitoring studies exist, only a limited number of ...
Experimental models of chemically induced Parkinson's disease in zebrafish at the embryonic larval stage: a systematic review [0.03%]
化学诱导的斑马鱼胚胎和幼体期帕金森病实验模型系统性回顾
Paola Briñez-Gallego,Dennis Guilherme da Costa Silva,Marcos Freitas Cordeiro et al.
Paola Briñez-Gallego et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra that results in a decrease in dopamine levels, resulting in motor-type disturbances. Different vertebrate mod...