Which prenatal biomarker is most appropriate for methylmercury dose-response for neurodevelopmental effects? [0.03%]
哪个产前生物标志物最适合用于甲基汞剂量-反应关系以评估其对神经发育的影响？
Leonid Kopylev,Michael Dzierlenga,Yu-Sheng Lin et al.
Leonid Kopylev et al.
Developmental neurotoxicity (DNT) is a well-established hazard attributed to methylmercury (MeHg) exposure. This evidence is based primarily upon includes studies that measured biomarkers of MeHg exposure in samples of maternal hair and blo...
Uncovering layer by layer the risk of nanoplastics to the environment and human health [0.03%]
揭开纳米塑料对环境和人类健康风险的面纱：层层递进的影响机制与暴露评估研究
Joana Cepeda da Silva Antunes,Paula Sobral,Vasco Branco et al.
Joana Cepeda da Silva Antunes et al.
Nanoplastics (NPs), defined as plastic particles with dimensions less than 100 nm, have emerged as a persistent environmental contaminant with potential risk to both environment and human health. Nanoplastics might translocate across biolog...
Review of non-invasive biomarkers as a tool for exposure characterization in human health risk assessments [0.03%]
非侵入式生物标志物在人类健康风险评估中的作用及暴露表征研究进展评述
N Shilnikova,F Momoli,N Karyakina et al.
N Shilnikova et al.
Blood and urine are historically the most frequent matrices used for measuring chemical levels in human biomonitoring studies. As biomonitoring programs are refreshed, consideration of specific priority substances and specific population ta...
Pablo Scharf,Michael Aschner,Sandra Farsky
Pablo Scharf
Neutrophils are the most abundant leukocytes in humans and essential for innate immune responses despite a short lifespan in the bloodstream. A complex and tightly regulated production of neutrophils is required to maintain host defense. Th...
Incorporating new approach methods (NAMs) data in dose-response assessments: The future is now! [0.03%]
剂量响应评估中纳入新方法数据：未来已来！
En-Hsuan Lu,Ivan Rusyn,Weihsueh A Chiu
En-Hsuan Lu
Regulatory dose-response assessments traditionally rely on in vivo data and default assumptions. New Approach Methods (NAMs) present considerable opportunities to both augment traditional dose-response assessments and accelerate the evaluat...
In vitro models to evaluate multidrug resistance in cancer cells: Biochemical and morphological techniques and pharmacological strategies [0.03%]
用于评估癌细胞多重耐药的体外模型：生化和形态学技术及药理学策略
Maria Fernanda Madrid,Eleicy Nathaly Mendoza,Ana Lizeth Padilla et al.
Maria Fernanda Madrid et al.
The overexpression of ATP-binding cassette (ABC) transporters contributes to the failure of chemotherapies and symbolizes a great challenge in oncology, associated with the adaptation of tumor cells to anticancer drugs such that these trans...
Local and systemic effects of microplastic particles through cell damage, release of chemicals and drugs, dysbiosis, and interference with the absorption of nutrients [0.03%]
微塑料颗粒通过细胞损伤、化学物质和药物释放、菌群失调以及干扰营养吸收所产生的局部及全身效应
Eleonore Fröhlich
Eleonore Fröhlich
Microplastic particles (MPs) have been detected in a variety of environmental samples, including soil, water, food, and air. Cellular studies and animal exposures reported that exposure to MPs composed of different polymers might result in ...
Neuroendocrine contribution to sex-related variations in adverse air pollution health effects [0.03%]
神经内分泌对空气污染不利健康影响的性别差异的影响
Devin I Alewel,Urmila P Kodavanti
Devin I Alewel
Air pollution exposure is ranked as a leading environmental risk factor for not only cardiopulmonary diseases but also for systemic health ailments including diabetes, reproductive abnormalities, and neuropsychiatric disorders, likely media...
Styrene lung cancer risk assessment: an alternative evaluation of human lung cancer risk assuming mouse lung tumors are potentially human relevant and operating by a threshold-based non-genotoxic mode of action [0.03%]
styrene肺癌风险评估：假设小鼠肺肿瘤可能与人类相关并在非遗传阈值模式下操作的人类肺癌风险的替代评估方法
J S Bus,S Su,W Li et al.
J S Bus et al.
Rodent inhalation studies indicate styrene is a mouse lung-specific carcinogen. Mode-of-action (MOA) analyses indicate that the lung tumors cannot be excluded as weakly quantitatively relevant to humans due to shared oxidative metabolites d...
An integrative exploration of environmental stressors on the microbiome-gut-brain axis and immune mechanisms promoting neurological disorders [0.03%]
整合探讨环境压力源对微生态-肠-脑轴及促进神经性疾病免疫机制的影响
Hajar Heidari,David A Lawrence
Hajar Heidari
The microbiome-gut-brain axis is altered by environmental stressors such as heat, diet, and pollutants as well as microbes in the air, water, and soil. These stressors might alter the host's microbiome and symbiotic relationship by modifyin...