Kenneth Orloff,Ketna Mistry,Susan Metcalf
Kenneth Orloff
Arsenic (As) is a widely occurring environmental contaminant. To assess human exposures to As, public health officials and researchers often conduct biomonitoring. Samples of urine, hair, nails, or blood are collected from potentially expos...
Genetic polymorphism in paraoxonase 1 (PON1): Population distribution of PON1 activity [0.03%]
血浆卵磷脂胆固醇酰基转移酶活性与载脂蛋白A-I及遗传多态性的关系研究进展
Gary Ginsberg,Patricia Neafsey,Dale Hattis et al.
Gary Ginsberg et al.
Paraoxonase-1 (PON1) is a serum esterase that hydrolyzes the activated oxon form of several organophosphates. The central role of PON1 in detoxification of organophosphate (OP) pesticides was demonstrated in knockout mouse studies, suggesti...
Genetic polymorphism in N-Acetyltransferase (NAT): Population distribution of NAT1 and NAT2 activity [0.03%]
N-乙酰基转移酶（NAT）的遗传多态性：NAT1和NAT2活性的群体分布
Katy Walker,Gary Ginsberg,Dale Hattis et al.
Katy Walker et al.
N-Acetyltransferases (NAT) are key enzymes in the conjugation of certain drugs and other xenobiotics with an arylamine structure. Polymorphisms in NAT2 have long been recognized to modulate toxicity produced by the anti-tubercular drug ison...
Genetic Polymorphism in Glutathione Transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity [0.03%]
谷胱甘肽转移酶(GST)的基因多态性：GSTM1，T1和P1连接活性的群体分布特征
Gary Ginsberg,Susan Smolenski,Dale Hattis et al.
Gary Ginsberg et al.
Glutathione transferases (GST) catalyze the conjugation of glutathione (GSH) with electrophiles, many of which may otherwise interact with protein or DNA. In select cases such as halogenated solvents, GST-mediated conjugation may lead to a ...
Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity [0.03%]
CYP2E1基因多态性及人群CYP2E1活性分布
Pat Neafsey,Gary Ginsberg,Dale Hattis et al.
Pat Neafsey et al.
Cytochrome P-450 2E1 (CYP2E1) is a key enzyme in the metabolic activation of a variety of toxicants including nitrosamines, benzene, vinyl chloride, and halogenated solvents such as trichloroethylene. CYP2E1 is also one of the enzymes that ...
Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity [0.03%]
细胞色素P450 2D6(CYP2D6)的遗传多态性：CYP2D6活性的种族分布
Patricia Neafsey,Gary Ginsberg,Dale Hattis et al.
Patricia Neafsey et al.
Cytochrome P-450 2D6 (CYP2D6) is involved in the metabolism of many therapeutic drugs even though the enzyme represents a small proportion of the total CYP content of human liver. In vivo phenotyping with probe drug substrates such as debri...
The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes [0.03%]
六种外源物质代谢酶基因多态性对人群变异影响的研究
Gary Ginsberg,Susan Smolenski,Patricia Neafsey et al.
Gary Ginsberg et al.
This review provides variability statistics for polymorphic enzymes that are involved in the metabolism of xenobiotics. Six enzymes were evaluated: cytochrome P-450 (CYP) 2D6, CYP2E1, aldehyde dehydrogenase-2 (ALDH2), paraoxonase (PON1), gl...
A review of current toxicological concerns on vanadium pentoxide and other vanadium compounds: gaps in knowledge and directions for future research [0.03%]
五氧化二钒及其他钒化合物的毒理学问题回顾：知识空白与未来研究方向建议
Farida Louise Assem,Leonard Stephen Levy
Farida Louise Assem
Vanadium pentoxide (V(2)O(5)) and other inorganic vanadium compounds have recently been evaluated by several occupational exposure limit (OEL) setting (occupational exposure limit, OEL) committees and expert groups in response to the public...
Recent advances in research on radiofrequency fields and health: 2004-2007 [0.03%]
2004-2007年关于射频场和健康研究的新进展
Riadh W Y Habash,J Mark Elwood,Daniel Krewski et al.
Riadh W Y Habash et al.
The widespread use of wireless telecommunications devices, particularly mobile phones and wireless networks, has resulted in increased human exposure to radiofrequency (RF) fields. Although national and international agencies have establish...
Jan L Lyche,Arno C Gutleb,Ake Bergman et al.
Jan L Lyche et al.
The purposes of this review are to (1) evaluate human and experimental evidence for adverse effects on reproduction and development in humans, produced by exposure to phthalates, and (2) identify knowledge gaps as for future studies. The wi...