Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk [0.03%]
美国EPA实施的计算毒理学：提供高通量决策支持工具，用于筛查和评估化学物质的暴露、危害和风险
Robert Kavlock,David Dix
Robert Kavlock
Computational toxicology is the application of mathematical and computer models to help assess chemical hazards and risks to human health and the environment. Supported by advances in informatics, high-throughput screening (HTS) technologie...
Melvin E Andersen,Mustafa Al-Zoughool,Maxine Croteau et al.
Melvin E Andersen et al.
In 2007, the U.S. National Research Council (NRC) released a report, "Toxicity Testing in the 21st Century: A Vision and a Strategy," that proposes a paradigm shift for toxicity testing of environmental agents. The vision is based on the no...
The U.S. Environmental Protection Agency strategic plan for evaluating the toxicity of chemicals [0.03%]
美国环保总署关于化学品毒性评价的战略计划
Michael Firestone,Robert Kavlock,Hal Zenick et al.
Michael Firestone et al.
In the 2007 report Toxicity Testing in the 21st Century: A Vision and a Strategy, the U.S. National Academy of Sciences envisioned a major transition in toxicity testing from cumbersome, expensive, and lengthy in vivo testing with qualitati...
Daniel Krewski,Daniel Acosta Jr,Melvin Andersen et al.
Daniel Krewski et al.
With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a Strategy, the U.S. National Academy of Sciences, in 2007, precipitated a major change in the way toxicity testing is conducted. It envisions increa...
Derivation of a melamine oral reference dose (RfD) and drinking-water total allowable concentration [0.03%]
从口服参考剂量（RfD）和饮用水容许总量角度对三聚氰胺进行推导
Virunya S Bhat,Gwen L Ball,Clifton J McLellan
Virunya S Bhat
Due to its high nitrogen content, melamine has been used to adulterate food to increase apparent protein content. In 2008, thousands of Chinese infants consumed reconstituted formula derived from melamine-adulterated milk. Urinary-tract sto...
Air pollution and effects on reproductive-system functions globally with particular emphasis on the Brazilian population [0.03%]
全球空气污染及其对生殖系统功能的影响——特别关注巴西人口
Mariana Matera Veras,Elia Garcia Caldini,Marisa Dolhnikoff et al.
Mariana Matera Veras et al.
In recent years, numerous studies showed that exposure to environmental air pollutants affected reproductive functions and, in particular, produced adverse effects on pregnancy outcomes, fertility, and fetal health. Epidemiological studies ...
Effects of radiofrequency electromagnetic fields on the human nervous system [0.03%]
无线电频率电磁场对人类神经系统的影响
Eric van Rongen,Rodney Croft,Jukka Juutilainen et al.
Eric van Rongen et al.
The effects of exposure to radiofrequency electromagnetic fields (EMF), specifically related to the use of mobile telephones, on the nervous system in humans have been the subject of a large number of experimental studies in recent years. T...
A new fibrin sealant from Crotalus durissus terrificus venom: applications in medicine [0.03%]
从特立尼达响尾蛇毒液中提取的新纤维蛋白封闭剂：医学应用
L C Barros,R S Ferreira Jr,S R C S Barraviera et al.
L C Barros et al.
Fibrin sealant, a widely available tissue adhesive, has been used since 1940 in a variety of clinical applications. Commercially available fibrin sealant products are synthesized from bovine thrombin and human fibrinogen, which may transmit...
Physiological and pharmacological significance of glutathione-conjugate transport [0.03%]
谷胱甘肽结合物转运的生理和药理意义
Yogesh C Awasthi,Pankaj Chaudhary,Rit Vatsyayan et al.
Yogesh C Awasthi et al.
Transport of the glutathione conjugates (GS-E) of electrophilic compounds generated during biotransformation of drugs and environmental pollutants is central to the mechanisms of defense against oxidative/electrophilic stress. In recent yea...
Toxicity studies on depleted uranium in primary rat cortical neurons and in Caenorhabditis elegans: what have we learned? [0.03%]
关于低浓度天然铀对大鼠皮质神经元和秀丽隐杆线虫毒性作用的研究：我们了解到了什么？
Michael Aschner,George C-T Jiang
Michael Aschner
Depleted uranium (DU) is the major by-product of the uranium enrichment process for its more radioactive isotopes, retaining approximately 60% of its natural radioactivity. Given its properties as a pyrophoric and dense metal, it has been e...