Elevated RTP801 promotes cell proliferation in non-small cell lung cancer [0.03%]
RTP801在非小细胞肺癌中促进肿瘤细胞增殖的功能研究
Jianyou Su,Hua Huang,Shaoqing Ju et al.
Jianyou Su et al.
Lung cancer, particularly non-small cell lung cancer (NSCLC), is one of main causes of mortality in cancer patients worldwide. It is necessary to seek effective biomarkers to improve diagnostic and therapeutic efficacies in human NSCLC. RTP...
Vibrio cholerae cytolysin: Multiple facets of the membrane interaction mechanism of a β-barrel pore-forming toxin [0.03%]
霍乱弧菌细胞溶解素：β-桶孔形成毒素的膜相互作用机制的多种表现形式
Reema Kathuria,Kausik Chattopadhyay
Reema Kathuria
Vibrio cholerae cytolysin (VCC) is a membrane-damaging protein toxin with potent cytolytic/cytotoxic activity against wide range of eukaryotic cells. VCC is a β-barrel pore-forming toxin (β-PFT), and it inflicts damage to the target cell ...
mRNA-Independent way to regulate translation elongation rate in eukaryotic cells [0.03%]
无mRNA情况下调控真核细胞翻译延伸速率的方法
Boris Negrutskii,Dmytro Vlasenko,Marc Mirande et al.
Boris Negrutskii et al.
The question of what governs the translation elongation rate in eukaryotes has not yet been completely answered. Earlier, different availability of different tRNAs was considered as a main factor involved, however, recent data revealed that...
Low BMI is correlated with increased TGF-β and IL-10 mRNA levels in the peripheral blood of breast cancer patients [0.03%]
低体质指数与乳腺癌患者外周血TGF-β和IL-10mRNA水平升高相关
Chao Liu,Qian Wang,Bing Sun et al.
Chao Liu et al.
Transforming growth factor-β (TGF-β), interleukin-10 (IL-10), and forkhead box P3 (Foxp3) have important roles in breast cancer development. Previous studies confirmed a correlation between these immune molecules and tumor characteristics...
Copper efflux transporters ATP7A and ATP7B: Novel biomarkers for platinum drug resistance and targets for therapy [0.03%]
铜离子流出转运蛋白ATP7A和ATP7B：顺铂耐药的新生物标志物及治疗靶点
Yue-Qin Li,Ji-Ye Yin,Zhao-Qian Liu et al.
Yue-Qin Li et al.
Platinum-based chemotherapy agents are widely used in the treatment of various solid malignancies. However, their efficacy is limited by drug resistance. Recent studies suggest that copper efflux transporters, which are encoded by ATP7A and...
The miR-203/SNAI2 axis regulates prostate tumor growth, migration, angiogenesis and stemness potentially by modulating GSK-3β/β-CATENIN signal pathway [0.03%]
miR-203/SNAI2轴通过调节GSK-3β/β-CATENIN信号通路潜在地调控前列腺肿瘤生长、迁移、血管生成和干细胞特性
Xinxin Tian,Fangfang Tao,Baotong Zhang et al.
Xinxin Tian et al.
Dysregulation of microRNA expression plays a pivotal role in the initiation and progression of a variety of human carcinomas including prostate cancer. Our previous studies have demonstrated that the silence of miR-203 contributes to the in...
Evaluation of autophagy induction on HEV 239 vaccine immune response in a mouse model [0.03%]
自噬诱导对HEV 239疫苗小鼠免疫反应的影响评价
Mehdi Khateri,Asghar Abdoli,Fatemeh Motevalli et al.
Mehdi Khateri et al.
Hepatitis E virus (HEV) infection remains a serious threat to life and productivity in developing world. Vaccine seems to be an effective, safe, and affordable approach to address HEV disease burden. The HEV genome consists of three open re...
Heterozygosis in aromatic amino acid decarboxylase deficiency: Evidence for a positive interallelic complementation between R347Q and R358H mutations [0.03%]
芳香族氨基酸脱羧酶缺乏症中杂合子的研究：R347Q和R358H突变间的互补作用证据
Riccardo Montioli,Giacomo Janson,Alessandro Paiardini et al.
Riccardo Montioli et al.
Aromatic amino acid or Dopa decarboxylase (AADC or DDC) is a homodimeric pyridoxal 5'-phosphate (PLP) enzyme responsible for the generation of the neurotransmitters dopamine and serotonin. AADC deficiency is a rare inborn disease caused by ...
Potential role of potassium and chloride channels in regulation of silymarin-induced apoptosis in Candida albicans [0.03%]
钾通道和氯通道在诱导白色念珠菌凋亡的水飞蓟素的调节中的潜在作用
Wonjong Lee,Dong Gun Lee
Wonjong Lee
Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver diseases. In our previous study, we reported that at concentrations above the minimal inhibitory concentration (MIC), silymarin ...
Association of genetic variants in the interleukin-18 gene promoter with risk of hepatocellular carcinoma and metastasis in patients with hepatitis C virus infection [0.03%]
白细胞介素-18基因启动子遗传多态性与丙肝相关肝癌发病及转移的关系研究
Noha M Bakr,Ashraf Awad,Emad A Moustafa
Noha M Bakr
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver, characterized by high vascularization and rapid tumor progression. The current case-control study aimed to analyze the influence of -607C/A and -137G/C polymorphisms in th...