Lipo-Glc-1,6-P2: A Bioprecursor Prodrug for Phosphomannomutase-2 Congenital Disorder of Glycosylation [0.03%]
Federica Sodano,Maria Monticelli,Bruno Hay Mele et al.
Federica Sodano et al.
Phosphomannomutase-2 (PMM2) deficiency leads to the prominent Congenital Disorder of Glycosylation (CDG), a rare disease currently lacking effective treatment options. The complete absence of PMM2 activity is incompatible with life, and all...
Heba Ibrahim Abd El-Moaty,Ahmed S Doghish,Shaza H Aly et al.
Heba Ibrahim Abd El-Moaty et al.
Angiogenesis, which is the formation of new blood vessels from existing vasculature, exhibits a pivotal role in breast cancer progression and promotes metastasis. This complex biological process is influenced by the dynamic balance of pro- ...
CYP17A1 Locus: Regulatory Mechanisms and Clinical Associations With Cardiovascular Disease and Metabolic Syndrome [0.03%]
CYP17A1 位点：调控机制及其与心血管疾病和代谢综合征的临床关联
Yasmine Chakkor,Redouane Aherrahrou
Yasmine Chakkor
The CYP17A1 gene encodes the P450 17α-hydroxylase/17,20-lyase protein, a key enzyme in steroidogenesis. In the past, it was associated with disorders such as congenital adrenal hyperplasia, disorders of sex development, and castration resi...
Future Prospects of Imatinib in Advanced Pulmonary Hypertension Management [0.03%]
伊马替尼在难治性肺动脉高压中的应用前景
Federica Davì,Stella Mangione,Antonella Iaconis et al.
Federica Davì et al.
Pulmonary arterial hypertension (PAH) is a severe, progressive disease characterized by elevated pulmonary arterial pressure and increased vascular resistance. This hemodynamic strain forces the right ventricle to pump against a high-pressu...
OTUD1 Relieves Coxsackievirus-Induced Ferroptosis and Inflammation in Myocardial Cells by Stabilizing NRF2 and Inhibiting NF-κB Signaling [0.03%]
OTUD1通过稳定NRF2和抑制NF-κB信号通路缓解柯萨奇病毒诱导的心肌细胞铁死亡和炎症
Yanfei Chen,Jingxuan Xiong,Yang Xiao et al.
Yanfei Chen et al.
Viral myocarditis (VMC) is a common inflammatory myocardial disease in children and is associated with heart failure and sudden cardiac death. Coxsackievirus B3 (CVB3) is the most common pathogen, and inflammation and ferroptosis are the ke...
POBS Relieves Antigen-Induced Experimental Sjögren's Disease by Regulating B Lymphocyte Subsets via CXCL13/CXCR5 Signaling Pathway [0.03%]
通过CXCL13/CXCR5信号通路调节B淋巴细胞亚群的POBS可缓解抗原诱导的实验性舍格伦综合征
Xiaosheng Lei,Na Li,Qiaolin Zhang et al.
Xiaosheng Lei et al.
Sjögren's Disease (SjD) is an autoimmune disorder characterized by lymphocyte infiltration into exocrine glands, leading to dry eyes and mouth. Its pathogenesis involves B cell hyperactivity and type I interferon activation. CXCL13 promote...
ALG8-Driven Metabolic Reprogramming in Polycystic Kidney Disease: A Systematic Synthesis of Evidence Linking Glycosylation Defects to Metabolic Signaling [0.03%]
ALG8介导的糖基化缺陷与多囊肾病代谢重塑的系统性证据总结及信号转导机制分析
Xiaoran Wang,Zhili Huang,Wen Zhang
Xiaoran Wang
Endoplasmic reticulum glycosyltransferase ALG8 controls metabolic fate in autosomal dominant polycystic kidney disease (ADPKD). In this paper, we summarize human genetics, cell-based, and organ-based evidence to investigate whether ALG8 var...
Cellular Mechanisms and Therapeutic Targeting of Long Noncoding RNAs in Atherosclerotic Disease [0.03%]
长非编码RNA在动脉粥样硬化病的细胞机制和治疗靶标研究
Rasha Abu-Khudir,Ahmed S Doghish,Mai A Abd-Elmawla et al.
Rasha Abu-Khudir et al.
To effectively combat atherosclerotic diseases, it is essential to identify novel biomarkers and therapeutic targets that can detect early-stage atherosclerosis before the development of high-risk, unstable plaques. Due to their distinct ch...
ADAM15 Is a Potential Biomarker for Pan-Cancer Prognosis and Immunotherapy: Validation in HCC and COAD [0.03%]
ADAM15是泛癌症预后和免疫治疗的潜在生物标志物：在HCC和COAD中的验证
Wenjia Guo,Yu&#x;e Liu,Wencong Ma et al.
Wenjia Guo et al.
A Disintegrin and metalloprotease (ADAM) family encompasses a diverse array of widely expressed proteases functioning in pathological processes. ADAM15 stands out as a pivotal mediator in multiple tumor types, responding to immune checkpoin...
Punicalagin Targets FDX1 to Induce Cuproptosis for the Treatment of Gastric Cancer [0.03%]
Punicalagin靶向FDX1诱导铜死亡用于胃癌治疗
Yuan-Yuan Fang,Si-Yi Zhang,Chuan-Yu Leng et al.
Yuan-Yuan Fang et al.
Gastric cancer represents the fifth most common malignancy globally and the third leading cause of cancer-related deaths. Due to its insidious early symptoms and frequent metastasis at diagnosis, the survival rate remains dismal. There is t...