MiR-127-3p inhibits cell growth and invasiveness by targeting ITGA6 in human osteosarcoma [0.03%]
miR-127-3p通过靶向ITGA6抑制人骨肉瘤细胞的生长和侵袭性
Dong Wang,Liang Tang,Huihui Wu et al.
Dong Wang et al.
Osteosarcoma (OS) is one of the most universal malignant bone tumors that occur mostly in children and adolescents. This study aimed to investigate the roles of miR-127-3p and integrin subunit-α 6 (ITGA6) in OS proliferation, apoptosis, in...
Asim Badar,Zarina Arif,Khursheed Alam
Asim Badar
Carbamylation (or carbamoylation) is a non-enzymatic modification of biomolecules mediated by cyanate, a dissociation product of urea. Proteins are more sensitive to carbamylation. Two major sites of carbamylation reaction are: Nα -amino m...
Memantine protects against ischemia/reperfusion-induced brain endothelial permeability [0.03%]
美金刚对缺血/再灌注所致脑内皮通透性损害具有保护作用
Yingying Liu,Yudiao Huang,Yueyue Xu et al.
Yingying Liu et al.
Increased transendothelial permeability and subsequent blood-brain barrier damage play a key role in the pathological progression of human brain ischemia and secondary reperfusion. Memantine is a licensed drug providing clinically relevant ...
Procyanidin-B2 enriched fraction of cinnamon acts as a proteasome inhibitor and anti-proliferative agent in human prostate cancer cells [0.03%]
肉桂中富含 Procyanidin-B2 的组分作为蛋白酶体抑制剂及前列腺癌细胞增殖抑制剂的作用
Srividya Gopalakrishnan,Harshavardhana H Ediga,S Sreenivasa Reddy et al.
Srividya Gopalakrishnan et al.
Altered activity of the proteolytic machine-the 26S proteasome is observed in many disease conditions. Hence, either inhibition or activation of the 26S proteasome is thought to be a novel therapy for treatment of certain diseases such as c...
SOCS1 is associated with clinical progression and acts as an oncogenic role in triple-negative breast cancer [0.03%]
SOCS1与临床病程进展相关并在三阴性乳腺癌中发挥致癌作用
Qian Qian,Yuetao Lv,Peng Li
Qian Qian
Suppressors of cytokine signaling 1 (SOCS1) is a member of SOCS family and acts as negative regulators of cytokine signaling by direct inhibition of receptor-associated janus kinases. The clinical significance and biological function of SOC...
Diagnostic and prognostic value of serum miR-15a and miR-16-1 expression among egyptian patients with prostate cancer [0.03%]
埃及前列腺癌患者血清miR-15a和miR-16-1表达的诊断及预后价值分析
Haidy E Zidan,Rehab S Abdul-Maksoud,Walid S H Elsayed et al.
Haidy E Zidan et al.
Prostate cancer (PCa) is considered the most common malignancy in men. The aim of this study is to assess the role of serum miR-15a and miR-16-1 expression in PCa development, diagnosis and prognosis aiming to find a specific noninvasive bi...
PCMT1 is an unfavorable predictor and functions as an oncogene in bladder cancer [0.03%]
PCMT1是膀胱癌的不良预测因子并作为致癌基因发挥作用
Liming Dong,Yanpei Li,Dongwei Xue et al.
Liming Dong et al.
The role of protein l-isoaspartate (d-aspartate) O-methyltransferase (PCMT1) in human cancer was generally cognized. The clinical significance and biological function of PCMT1 in bladder cancer is still unknown. PCMT1 mRNA and protein expre...
Extract of Euryale ferox Salisb exerts antidepressant effects and regulates autophagy through the adenosine monophosphate-activated protein kinase-UNC-51-like kinase 1 pathway [0.03%]
石莲草提取物具有抗抑郁作用并通过腺苷酸活化蛋白激酶-类神经病溃疡蛋白激酶1信号通路调节自噬
Zhiheng Huang,Xiaoyan Huang,Qian Wang et al.
Zhiheng Huang et al.
Positive regulation of autophagy by Euryale ferox Salisb (ES) leads to antidepressant effects. This study focused on the potential antidepressant mechanisms induced by the petroleum ether fraction of ES (ES-PE) in the chronically unpredicta...
LncRNA UCA1 impacts cell proliferation, invasion, and migration of pancreatic cancer through regulating miR-96/FOXO3 [0.03%]
长链非编码RNA UCA1通过调节miR-96/FOXO3影响胰腺癌细胞增殖、侵袭和迁移
Yongping Zhou,Yigang Chen,Wenzhou Ding et al.
Yongping Zhou et al.
This study was expected to reveal the regulatory effects of lncRNA UCA1 on pancreatic cancer cell progression through targeting miR-96/FOXO3. Microarray analysis was carried out on 36 cases of pancreatic cancer tissues and 16 cases of adjac...
Aberrant KIF20A expression might independently predict poor overall survival and recurrence-free survival of hepatocellular carcinoma [0.03%]
KIF20A异常表达可能独立预示肝细胞癌不良总体生存和无复发生存率
Mingqin Lu,Xiaoying Huang,Yongping Chen et al.
Mingqin Lu et al.
Kinesin family member 20A (KIF20A) is an essential regulator of cytokinesis. In this study, by performing a retrospective study based on data from the Cancer Genome Atlas (TCGA)-Liver and Hepatocellular Carcinoma (LIHC) cohort, we tried to ...