Effect of resveratrol on doxorubicin resistance in breast neoplasm cells by modulating PI3K/Akt signaling pathway [0.03%]
茋通过调节PI3K/Akt信号通路影响其对乳腺肿瘤细胞多柔比星耐药性的作用研究
Ju-Min Chen,Jun-Yun Bai,Kun-Xian Yang
Ju-Min Chen
In the study, we probed into the effect of Resveratrol (RES) on Doxorubicin (DOX)-resistant breast neoplasm cell line MCF-7/DOX as well as the mechanism of RES underlying the DOX-resistant breast cancer. CCK-8 assay was utilized to assess t...
Nordihydroguaiaretic acid can suppress progression of experimental autoimmune encephalomyelitis [0.03%]
Nordihydroguaiaretic酸可以抑制实验性自身免疫性脑脊髓炎的发展
Liang Wang,Lin Li,Mo-Yuan Quan et al.
Liang Wang et al.
Multiple sclerosis (MS) is a poorly understood disease mechanistically. MOG35-55 peptide induced experimental autoimmune encephalomyelitis (EAE) is a broadly used model to study MS. Using this model we have earlier shown that the antioxidan...
Discriminating gastric cancer and gastric ulcer using human plasma amino acid metabolic profile [0.03%]
基于人血浆氨基酸代谢谱的胃癌与胃溃疡鉴别诊断研究
Fangyu Jing,Xin Hu,Yunfeng Cao et al.
Fangyu Jing et al.
Patients with gastric ulcer (GU) have a significantly higher risk of developing gastric cancer (GC), especially within 2 years after diagnosis. The main way to improve the prognosis of GC is to predict the tumorigenesis and metastasis in th...
Impact of wedelolactone in the anti-glycation and anti-diabetic activity in experimental diabetic animals [0.03%]
Wedelolactone对实验性糖尿病动物抗糖基化和抗糖尿病活性的影响
Uzma Shahab,Mohammad Faisal,Abdulrahman A Alatar et al.
Uzma Shahab et al.
The glycation reaction is the addition of free carbonyl group of reducing sugar to the free amino groups of proteins, lipoproteins and nucleic acids which results in the formation of an Amadori product which may ultimately lead to the gener...
Caffeic acid phenethyl ester guards against benign prostate hypertrophy in rats: Role of IGF-1R/protein kinase-B (Akt)/β-catenin signaling [0.03%]
咖啡酸苯乙酯通过调节IGF-1R/蛋白激酶-B( Akt)/ β-连环素信号通路预防良性前列腺肥大
Hany A Omar,Mai F Tolba
Hany A Omar
Benign prostate hypertrophy (BPH) is among the most common diseases with a huge impact on the quality of life of elderly men. There is a current need for the development of well-tolerated and effective preventive strategies to improve the c...
Svetlana E Soboleva,Tat&#x;yana A Guschina,Georgy A Nevinsky
Svetlana E Soboleva
It is known that that human serum albumin (HSA) and alpha-lactalbumin (LA) possess DNA-binding sites. Electrophoretically homogeneous HSA and LA containing no canonical enzymes were isolated from human sera and milk. Here we have analyzed f...
Effect of histone deacetylase inhibitor on epithelial-mesenchymal transition of liver fibrosis [0.03%]
组蛋白去乙酰化酶抑制剂对肝纤维化上皮间质转化的影响研究
Maggie M Ramzy,Hend M Abdelghany,Nagwa M Zenhom et al.
Maggie M Ramzy et al.
Liver fibrosis is an excessively reversible wound healing process and the fibrotic disorder is the activation of hepatic stellate cell that requires extensive alterations in gene expression. As reversible deacetylation of histone proteins m...
Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses [0.03%]
细菌和病毒生理学及发病机理中的硫化氢作用
Virender Kumar Pal,Parijat Bandyopadhyay,Amit Singh
Virender Kumar Pal
An increasing number of studies have established hydrogen sulfide (H2 S) gas as a major cytoprotectant and redox modulator. Following its discovery, H2 S has been found to have pleiotropic effects on physiology and human health. H2 S acts a...
Anxiolytic effect of anacardic acids from cashew (Anacardium occidentale) nut shell in mice [0.03%]
澳洲胡桃果壳中安卡idine酸的抗焦虑作用
Antonio Luiz Gomes Júnior,Jana Dimitrova Tchekalarova,Keylla da Conceição Machado et al.
Antonio Luiz Gomes Júnior et al.
Antianxiety drugs currently in use are associated with a number of serious side effects. Present study was designed to evaluate the efficacy of anacardic acids (AAs) isolated from cashew nut (Anacardium occidentale L.) shell liquid (CNSL) t...
Glenn F W Walpole,Sergio Grinstein,Johannes Westman
Glenn F W Walpole
Innate immunity relies on the effective recognition and elimination of pathogenic microorganisms. This entails sequestration of pathogens into phagosomes that promptly acquire microbicidal and degradative properties. This complex series of ...