Telomerase reverse transcriptase suppression inhibits cell proliferation and promotes cell apoptosis in hepatocellular cancer [0.03%]
端粒酶逆转录酶抑制对肝细胞癌增殖和凋亡的影响研究
Yanfeng Shen,Feng Xi,Haibin Li et al.
Yanfeng Shen et al.
We aimed to investigate the role of telomerase reverse transcriptase (TERT) in hepatocellular cancer (HCC) cells. R software was used for differential expressed gene analysis. Western blot and quantitative real time polymerase chain reactio...
MicroRNA-223 inhibits lipopolysaccharide-induced inflammatory response by directly targeting Irak1 in the nucleus pulposus cells of intervertebral disc [0.03%]
microRNA-223通过直接靶向椎间盘核盘细胞中的Irak1抑制脂多糖诱导的炎症反应
Hua Wang,Pan Hao,Hu Zhang et al.
Hua Wang et al.
This study was aimed to research the effect of miR-223 on the inflammatory responses induced by lipopolysaccharide (LPS) in nucleus pulposus (NP) cells of rat intervertebral disc. Isolated rat NP cells were induced by LPS. Reverse transcrip...
Biochemical and biophysical studies of Helicobacter pylori arginine decarboxylase, an enzyme important for acid adaptation in host [0.03%]
乌氏幽门螺杆菌精氨酸脱羧酶的生化及生物物理研究——一种对酸适应性有重要作用的酶
Mashkoor Alam,Abhishek Srivastava,Ankita Dutta et al.
Mashkoor Alam et al.
Despite importance of arginine decarboxylase (ADC: EC 4.1.1.19) of Helicobacter pylori (H. pylori) 26695 pathogenic strain for acid adaptation in host, the enzyme has not yet been studied at a molecular level. Using combined approaches that...
Recent advances in understanding Leishmania donovani infection: The importance of diverse host regulatory pathways [0.03%]
近年来利什曼原虫(杜氏利什曼原虫)感染研究的进展：多种宿主调控途径的重要性
Amrita Saha,Moumita Basu,Anindita Ukil
Amrita Saha
Invasion of host cell by pathogens induce various intracellular signalling pathways. The host cell through the initiation of these signalling circuits desperately wants to get rid of the pathogen, whereas the pathogen tries to subvert these...
Generating anchors only to lose them: The unusual story of glycosylphosphatidylinositol anchor biosynthesis and remodeling in yeast and fungi [0.03%]
仅生成又丢失的定位信号：酵母及真菌细胞膜 GPI 连接蛋白合成与重塑机制研究
Sneha Sudha Komath,Sneh Lata Singh,Vavilala A Pratyusha et al.
Sneha Sudha Komath et al.
Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are present ubiquitously at the cell surface in all eukaryotes. They play a crucial role in the interaction of the cell with its external environment, allowing the cell to recei...
MiR-490-3p inhibits autophagy via targeting ATG7 in hepatocellular carcinoma [0.03%]
miR-490-3p通过靶向ATG7抑制自噬在肝癌中的作用
Yingliang Ou,Jiafa He,Yubin Liu
Yingliang Ou
The miR-490-3p was transfected into HepG2 cells to explore the correlation between miR-490-3p and hepatocellular carcinoma cell proliferation, apoptosis, and autophagy and its downstream target gene ATG7. Then we could possibly provide a me...
USP4 expression independently predicts favorable survival in lung adenocarcinoma [0.03%]
USP4表达在肺腺癌患者中独立预后生存期的良好指标
Ming Zhong,Qi Jiang,Ronghui Jin
Ming Zhong
Ubiquitin specific protease 4 (USP4) is a member of the USPs family, which catalyzes the cleavage of ubiquitin from a series of protein substrates, thereby modulating a number of cellular signaling pathways. In this study, we aimed to explo...
The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle [0.03%]
谷胱甘肽循环：超越γ-谷氨酰胺循环的谷胱甘肽代谢
Anand Kumar Bachhawat,Shambhu Yadav
Anand Kumar Bachhawat
Glutathione was discovered in 1888, over 125 years ago. Since then, our understanding of various functions and metabolism of this important molecule has grown over these years. But it is only now, in the last decade, that a somewhat complet...
MicroRNA-21 drives the switch to a synthetic phenotype in human saphenous vein smooth muscle cells [0.03%]
microRNA-21通过促进人的大隐静脉平滑肌细胞向合成表型转化来诱导内膜增生性疾病的发展
Aliah R Alshanwani,Kirsten Riches-Suman,David J O&#x;Regan et al.
Aliah R Alshanwani et al.
Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant remodelling and ...
L-rhamnose induces browning in 3T3-L1 white adipocytes and activates HIB1B brown adipocytes [0.03%]
D-核糖诱导3T3-L1白色脂肪细胞褐变并激活HIB1B棕色脂肪细胞
Minji Choi,Sulagna Mukherjee,Nam Hyeon Kang et al.
Minji Choi et al.
Induction of the brown adipocyte-like phenotype in white adipocytes (browning) is considered as a novel strategy to fight obesity due to the ability of brown adipocytes to increase energy expenditure. Here, we report that L-rhamnose induced...