MicroRNA-1270 is associated with poor prognosis and its inhibition yielded anticancer mechanisms in human osteosarcoma [0.03%]
微小核糖核酸-1270与不良预后相关且其抑制可产生人类骨肉瘤的抗癌机制
Lei Zhong,Changjun Zheng,Hongjuan Fang et al.
Lei Zhong et al.
In this work, we explored the aberrant expression pattern, clinical association, and functional regulations of microRNA-1270 (miR-1270) in osteosarcoma. Among in vitro osteosarcoma cell lines and in situ tissues of osteosarcoma patients, qu...
Amogh Kulkarni,Ajay Kumar Sharma,Harinath Chakrapani
Amogh Kulkarni
The emergence of drug resistance has posed a major challenge to treatment of tuberculosis worldwide. The new drug candidates in the pipeline are few and therefore there is an urgent need to develop antimycobacterials with novel mechanisms o...
Recent advances for identification of new scaffolds and drug targets for Mycobacterium tuberculosis [0.03%]
用于鉴定抗结核病新骨架及药物靶点的最新研究进展
Rohan Dhiman,Ramandeep Singh
Rohan Dhiman
Tuberculosis (TB) is a leading cause of mortality and morbidity with an estimated 1.7 billion people latently infected with the pathogen worldwide. Clinically, TB infection presents itself as an asymptomatic infection, which gradually manif...
Nisha Singh,Zeeshan Ahmad,Navin Baid et al.
Nisha Singh et al.
Infectious diseases are a major challenge in management of human health worldwide. Recent literature suggests that host immune system could be modulated to ameliorate the pathogenesis of infectious disease. Heme oxygenase (HMOX1) is a key r...
Anuradha Kumari,Dulal Panda
Anuradha Kumari
The centrosome executes diverse functions including the nucleation and organization of microtubules. A subset of centrosomal proteins is found to be involved in regulating the nucleation, stability, and dynamics of microtubules. Literature ...
Integrated microRNA and mRNA sequencing analysis of age-related changes to mouse thymic epithelial cells [0.03%]
整合微核糖核酸和信使核糖核酸测序分析小鼠胸腺上皮细胞的年龄相关变化
Hong-Ling Jia,Xiao-Qin Zeng,Feng Huang et al.
Hong-Ling Jia et al.
MicroRNAs (miRNAs) play key roles in the regulation of gene expression during multiple physiological processes, including early development, differentiation, and ageing. However, their involvement in age-related thymic involution is not cle...
β-lactam resistance: The role of low molecular weight penicillin binding proteins, β-lactamases and ld-transpeptidases in bacteria associated with respiratory tract infections [0.03%]
β-内酰胺耐药性：低分子量青霉素结合蛋白、β-内酰胺酶和ld-转肽酶在与呼吸道感染相关的细菌中的作用
Christopher S Ealand,Edith E Machowski,Bavesh D Kana
Christopher S Ealand
Disruption of peptidoglycan (PG) biosynthesis in the bacterial cell wall by β-lactam antibiotics has transformed therapeutic options for bacterial infections. These antibiotics target the transpeptidase domains in penicillin binding protei...
Upregulated lncRNA ADAMTS9-AS2 suppresses progression of lung cancer through inhibition of miR-223-3p and promotion of TGFBR3 [0.03%]
长链非编码RNA ADAMTS9-AS2通过抑制miR-223-3p并促进TGFBR3在肺癌症进展中的表达上调发挥抑癌作用
Chao Liu,Zuozhang Yang,Zhiyong Deng et al.
Chao Liu et al.
In this study, we aimed at investigating effects of lncRNA ADAMTS9-AS2 on lung cancer progression through regulating miR-223-3p and TGFBR3 expressions. Expressions of ADAMTS9-AS2 in lung cancer tissues and cell lines were determined by reve...
Increased neutrophil-lymphocyte ratio independently predicts poor survival in non-metastatic triple-negative breast cancer patients [0.03%]
中性粒细胞与淋巴细胞比值升高可独立预测三阴性乳腺癌患者预后不良
Xiangting Qiu,Yucui Song,Yanxiang Cui et al.
Xiangting Qiu et al.
Inflammation plays an important role in tumor initiation, progression, and metastasis. The neutrophil-lymphocyte ratio (NLR) is widely used to evaluate global inflammation in various tumor types. However, the prognostic role of NLR in non-m...
Mycobacterium tuberculosis Reporter Strains as Tools for Drug Discovery and Development [0.03%]
荧光/发光结核分枝杆菌报告菌株在药物研发中的应用
Robert B Abramovitch
Robert B Abramovitch
Reporter strains have proven to be powerful tools to study Mycobacterium tuberculosis (Mtb) physiology. Transcriptional and translational reporter strains are engineered by fusing a readout gene, encoding a fluorescent, luminescent or enzym...