Orexins Facilitates Osteogenic Differentiation of MC3T3-E1 Cells [0.03%]
下丘脑刺食素促进MC3T3-E1细胞成骨分化的功能及机制研究
Xuesong Han,Jicheng Zhou,Wei Peng
Xuesong Han
Dysfunction of osteoblastic bone formation and matrix mineralization plays a key role in the pathological development of osteoporosis. The orexin peptide orexin-A, a highly excitatory neuropeptide hormone, possesses various biological funct...
Energy Producing Metabolic Pathways in Functional Regulation of the Hematopoietic Stem Cells [0.03%]
造血干细胞功能调控的产能源代谢通路
Irene M Roy,Atreyi Biswas,Catherine Verfaillie et al.
Irene M Roy et al.
The hematopoietic system has a very well-studied hierarchy with the long-term (LT) hematopoietic stem cells (HSCs) taking the top position. The pool of quiescent adult LT-HSCs generated during the fetal and early postnatal life acts as a re...
Centromere and its associated proteins-what we know about them in Plasmodium falciparum [0.03%]
裂殖酵母着丝粒及其相关蛋白质——恶性疟原虫中我们所知道的内容
Garima Verma,Namita Surolia
Garima Verma
The complex life cycle of intracellular parasitic protozoans entails multiple rounds of DNA replication and mitosis followed by cytokinesis to release daughter parasites. To gain insights into mitotic events it is imperative to identify the...
Have we realized the full potential of β-lactams for treating drug-resistant TB? [0.03%]
我们已经充分挖掘了β-内酰胺类药物治疗耐药结核病的潜力了吗？
Elizabeth Story-Roller,Gyanu Lamichhane
Elizabeth Story-Roller
β-lactams are the most widely used antibiotics and are effective against a spectrum of pathogenic bacteria. Here, we focus on the state-of-the-art understanding of the molecular underpinnings that determine the overall efficacy of β-lacta...
CIN-TCP transcription factors: Transiting cell proliferation in plants [0.03%]
植物中的CIN-TCP转录因子：穿越细胞增殖
Kavitha Sarvepalli,Utpal Nath
Kavitha Sarvepalli
Leaves are the most conspicuous planar organs in plants, designed for efficient capture of sunlight and its conversion to energy that is channeled into sustaining the entire biosphere. How a few founder cells derived from the shoot apical m...
Genome wide analysis of meiotic recombination in yeast: For a few SNPs more [0.03%]
酵母减数分裂重组的基因组分析：少数SNP片段更多
Parijat Chakraborty,Ajith V Pankajam,Abhishek Dutta et al.
Parijat Chakraborty et al.
Diploid organisms undergo meiosis to produce haploid germ cells. Crossover events during meiosis promote genetic diversity and facilitate accurate chromosome segregation. The baker's yeast Saccharomyces cerevisiae is extensively used as a m...
Targeting the messengers: Serine/threonine protein kinases as potential targets for antimycobacterial drug development [0.03%]
针对信使：丝氨酸/苏氨酸蛋白激酶作为抗分枝杆菌药物研发的潜在靶点
Mehak Zahoor Khan,Prabhjot Kaur,Vinay Kumar Nandicoori
Mehak Zahoor Khan
The emergence of increasingly drug-resistant Mycobacterium tuberculosis strains has become a crucial public health concern. In order to effectively treat tuberculosis, it is imperative to find newer drug targets, which are important for the...
Genetic association between SHANK2 polymorphisms and susceptibility to autism spectrum disorder [0.03%]
SHANK2基因多态性与自闭症谱系障碍的易感性相关性研究
Ye Bai,Shuang Qiu,Yan Li et al.
Ye Bai et al.
Autism spectrum disorder (ASD), as one of early-onset neurodevelopmental disorders, is characterized by the following symptoms, including repetitive and stereotyped behaviors, impairments in social interaction, and dysfunctions in communica...
Drug permeation and metabolism in Mycobacterium tuberculosis: Prioritising local exposure as essential criterion in new TB drug development [0.03%]
结核分枝杆菌中药物的渗透和代谢：在新结核病药物开发中将局部暴露作为重要指标优先考虑
Lloyd Tanner,Paolo Denti,Lubbe Wiesner et al.
Lloyd Tanner et al.
Anti-tuberculosis (TB) drugs possess diverse abilities to penetrate the different host tissues and cell types in which infecting Mycobacterium tuberculosis bacilli are located during active disease. This is important since there is increasi...
The role of two-component systems in the physiology of Mycobacterium tuberculosis [0.03%]
两类调控系统在结核分枝杆菌生理学中的作用
Manikuntala Kundu
Manikuntala Kundu
Tuberculosis is a global health problem, with a third of the world's population infected with the bacillus, Mycobacterium tuberculosis. The problem is exacerbated by the emergence of multidrug resistant and extensively drug resistant strain...