Brazilin induces T24 cell death through c-Fos and GADD45β independently regulated genes and pathways [0.03%]
巴西灵通过独立调节的c-Fos和GADD45β基因及途径诱导T24细胞死亡
Tingting Zhang,Jiao He,Shuaina Zhang et al.
Tingting Zhang et al.
Purified Brazilin from Sappan wood extract has been reported with significant antitumor effect, especially on human T24 cells and bladder cancer mouse models. Brazilin can significantly induce expression of c-Fos and GADD45β and transfecti...
Mycotoxin-assisted mitochondrial dysfunction and cytotoxicity: Unexploited tools against proliferative disorders [0.03%]
霉菌毒素介导的线粒体功能障碍和细胞毒性：对抗增生性疾病的未开发工具
Muhammad Torequl Islam,Siddhartha Kumar Mishra,Swati Tripathi et al.
Muhammad Torequl Islam et al.
Mitochondria are the powerhouse of cells, which upon dysfunctions may lead to several diseases. Mycotoxins are the toxic secondary metabolites from fungi which are capable of causing diseases and death in humans and animals. They have a ver...
Chemical Crosslinking-Mass Spectrometry (CXL-MS) for Proteomics, Antibody-Drug Conjugates (ADCs) and Cryo-Electron Microscopy (cryo-EM) [0.03%]
用于组学、抗体药物偶联物（ADC）和冷冻电子显微镜（cryo-EM）的化学交联-质谱技术(CXL-MS)
Shreya Pal,Keerthiga Ganesan,Sambasivan Eswaran
Shreya Pal
Chemical crosslinking-mass spectrometry (CXL-MS) has emerged as a powerful tool in structural biology to elucidate protein-protein interactions. This review throws light on the advent of these technologies incorporating chemical crosslinkin...
Small Heat Shock Proteins B1 and B6: Which One is the Most Effective Adjuvant in Therapeutic HPV Vaccine? [0.03%]
小热休克蛋白B1和B6：哪一种是治疗性HPV疫苗中最有效的免疫佐剂？
Azam Bolhassani,Sepideh Shahbazi,Alireza Milani et al.
Azam Bolhassani et al.
Therapeutic human papillomaviruse (HPV) vaccines have the potential to inhibit the tumor growth by targeting HPV E6 and E7 oncoproteins. Among different vaccine strategies, DNA and protein-based approaches are the most effective candidates ...
Understanding the Role of Escherichia coli Hydrogenases and Formate Dehydrogenases in the FO F1 -ATPase Activity during the Mixed Acid Fermentation of Mixture of Carbon Sources [0.03%]
电子受体缺失对复合碳源发酵过程中厌氧呼吸代谢的影响研究
Heghine Gevorgyan,Armen Trchounian,Karen Trchounian
Heghine Gevorgyan
During fermentation Escherichia coli produces di-hydrogen (H2 ) via reversible membrane-bound [Ni-Fe]-hydrogenases (Hyd). This study describes the total and N,N'-dicyclohexylcarbodiimide (DCCD) inhibited ATPase activity and H2 production at...
Phosphomimetic Mutation Destabilizes the Central Core Domain of Human p53 [0.03%]
磷模拟突变使人类p53中央核心结构域不稳定
Johnson Wahengbam Luwang,Ramanathan Natesh
Johnson Wahengbam Luwang
Transcriptional activity of p53 is modulated by various posttranslational modifications. Earlier studies have reported that Aurora B phosphorylation of p53 leads to loss of its transcriptional activity, subsequently leading to its ubiquitin...
Iqra Sarfraz,Azhar Rasul,Ghulam Hussain et al.
Iqra Sarfraz et al.
Reprogrammed metabolic profile is a biochemical fingerprint of cancerous cells, which represents one of the "hallmarks of cancer." The aberrant expression pattern of enzymatic machineries orchestrates metabolic activities into a platform th...
Mycobacterium tuberculosis: Surviving and Indulging in an Unwelcoming Host [0.03%]
结核分枝杆菌：在不欢迎的宿主体内生存与繁殖
Archita Mishra,Avadhesha Surolia
Archita Mishra
More than a century has passed since the identification of Mycobacterium tuberculosis (Mtb) as the causative agent of tuberculosis (TB), we still are nowhere close to eradicating this deadly disease. Moreover, emergence of new drug-resistan...
Crystal structure of phospholipase A2 in complex with 1-naphthaleneacetic acid [0.03%]
与1-萘甲酸复合的磷脂酶A2晶体结构
Kalarickal V Dileep,Chandran Remya,Ignatius Tintu et al.
Kalarickal V Dileep et al.
Phospholipase A2 (PLA2 ) is one of the rate limiting enzymes involved in the production of arachidonic acid, a potent inflammatory mediator. PLA2 is widely distributed all over the animal kingdom. It is also seen in inflammatory exudation a...
Cleetus Cherupanakkal,Daisy Mariya Samadanam,Krishna Raja Muthuraman et al.
Cleetus Cherupanakkal et al.
Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with feb...