Autophagy induction plays time-dependent role in viral load of HCV infected Huh7.5 cell line [0.03%]
自噬诱导在HCV感染的Huh7.5细胞系中的病毒载量中起时间依赖性作用
Mohsen Abdoli,Asghar Abdoli,Ehsan Aryan et al.
Mohsen Abdoli et al.
Autophagy provides an initial membranous platform for incoming hepatitis C virus (HCV) RNA translation and immune evasion. Once HCV replication is established, this infrastructure will be unnecessary for translation of HCV RNA progeny. So, ...
Long noncoding RNA FAL1 promotes proliferation and inhibits apoptosis of human colon cancer cells [0.03%]
长链非编码RNA FAL1促进人类结肠癌细胞的增殖并抑制其凋亡
Kaiming Wu,Ning Zhang,Jun Ma et al.
Kaiming Wu et al.
Aberrant expression of long non-coding RNAs (lncRNAs) has been associated with a variety of malignancies including colon cancer. In this study, we aimed to characterize the biological mechanisms of focally amplified lncRNA on chromosome 1 (...
An in vitro and in vivo study of the role of long non-coding RNA-HOST2 in the proliferation, migration, and invasion of human glioma cells [0.03%]
长链非编码RNA-HOST2在人胶质瘤细胞增殖、迁移和侵袭中的作用的体外及体内研究
Qi Wang,Zhong-Wei Zhuang,Yi-Ming Cheng et al.
Qi Wang et al.
Gliomas are the most commonly occurring primary malignant brain tumors in the central nervous system of adults. They are rarely curable and the prognosis for high grade gliomas is generally poor. Recently, long non-coding RNA (lncRNA) human...
NT5E inhibition suppresses the growth of sunitinib-resistant cells and EMT course and AKT/GSK-3β signaling pathway in renal cell cancer [0.03%]
NT5E抑制可阻抑肾细胞癌索坦抵抗细胞的增殖及上皮间质转化表型和AKT/GSK-3β信号途径
Dan Peng,Zhiquan Hu,Xian Wei et al.
Dan Peng et al.
We aimed to explore the mechanisms of sunitinib-resistance in renal cell cancer (RCC) and provide new therapeutic evidence and biomarkers for RCC treatment using human clear-cell renal cell carcinoma (ccRCC) cell line, 786-O. Microarray ana...
Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer [0.03%]
miR-330-3p调节胃癌中促肿瘤分子SPHK1的表达及功能
Zhihua Wang,Huajun Qu,Wenjing Gong et al.
Zhihua Wang et al.
We intended to clarify the role of sphingosine kinase 1 (SPHK1) in gastric cancer (GC) using both in vitro and in vivo assays. The study was designed to identify novel therapeutic targets for GC treatment. Differential analysis was utilized...
Poly r(C) Binding Protein 1 Regulates Posttranscriptional Expression of the Ubiquitin Ligase TRIM56 in Ovarian Cancer [0.03%]
聚r(C)结合蛋白1通过调节泛素连接酶TRIM56的翻译后表达促进卵巢癌发展
Lei Zhao,Zhi-Gang Wang,Ping Zhang et al.
Lei Zhao et al.
Our earlier work has shown that the E3 ligase TRIM56 messenger RNA (mRNA) level and vimentin protein expression followed an inverse correlation in ovarian carcinoma patients; however, the regulatory mechanisms underlying TRIM56 expression i...
Does mitochondrial DNA evolution in metazoa drive the origin of new mitochondrial proteins? [0.03%]
动物线粒体DNA的进化是否驱动新的线粒体蛋白的产生？
S L van Esveld,M A Huynen
S L van Esveld
Most eukaryotic cells contain mitochondria with a genome that evolved from their α-proteobacterial ancestor. In the course of eukaryotic evolution, the mitochondrial genome underwent a dramatic reduction in size, caused by the loss and tra...
Calcium-regulated mitochondrial ATP-Mg/Pi carriers evolved from a fusion of an EF-hand regulatory domain with a mitochondrial ADP/ATP carrier-like domain [0.03%]
一种由EF手征调控结构域与线粒体ADP/ATP载体样结构域融合而来的钙调节型线粒体ATP-Mg/Pi载体的演化
Steven P D Harborne,Edmund R S Kunji
Steven P D Harborne
The mitochondrial ATP-Mg/Pi carrier is responsible for the calcium-dependent regulation of adenosine nucleotide concentrations in the mitochondrial matrix, which allows mitochondria to respond to changing energy requirements of the cell. Th...
Exosomes from human placenta purified by affinity chromatography on sepharose bearing immobilized antibodies against CD81 tetraspanin contain many peptides and small proteins [0.03%]
通过固定针对CD81四配体的抗体的交联琼脂糖亲和色谱纯化的来自人类胎盘的外泌体含有许多肽和小蛋白
Evgeniya E Burkova,Pavel S Dmitrenok,Dmitrii V Bulgakov et al.
Evgeniya E Burkova et al.
Exosomes are nanovesicles (40-100 nm) containing various RNAs and different proteins. Exosomes are involved in intracellular communication and immune system function. Exosomes from different sources are usually isolated using standard metho...
Giovanna De Simone,Fabio Polticelli,Silvio Aime et al.
Giovanna De Simone et al.
Rare earth elements play a pivotal role in high-technology devices, are used as contrast agents for magnetic resonance imaging in clinical settings, are explored as drug carriers for tumor photodynamic therapy, and are used as fertilizers. ...