CRYAB is upregulated and predicts clinical prognosis in kidney renal clear cell carcinoma [0.03%]
CRYAB在肾透明细胞癌中表达上调并可作为预后标志物
Hao Ren,Xinyu Chen,Meiling Ji et al.
Hao Ren et al.
Clear cell renal cell carcinoma (KIRC) is the most prevalent subtype of renal cell carcinoma (RCC), accounting for 70% to 80% of all RCC cases. The CRYAB (αB-crystallin) gene is broadly expressed across various human tissues, yet its role ...
Tinagl1 restores tamoxifen sensitivity and blocks fibronectin-induced EMT by simultaneously blocking the EGFR and β1-integrin/FAK signaling pathways in tamoxifen-resistant breast cancer cells [0.03%]
Tinagl1通过同时阻断EGFR和β1-整合素/FAK信号通路来恢复乳腺癌细胞中tamoxifen的敏感性并阻止纤连蛋白诱导的上皮间质转化（EMT）（耐药细胞）
Jie Yuan,Li Yuan,Li Yang et al.
Jie Yuan et al.
Tamoxifen (TAM) is employed to treat premenopausal ER-positive breast cancer patients, but TAM resistance is the main reason affecting its efficacy. Thus, addressing TAM resistance is crucial for improving therapeutic outcomes. This study e...
APOC1 inhibit NKTCL doxorubicin sensitivity by promoting mitophagy [0.03%]
APOC1通过促进线粒体自噬抑制NKTCL的多柔比星敏感性
Sa Xiao,Jing Kuang,Jiamei Yang et al.
Sa Xiao et al.
NKTCL is a highly aggressive malignant tumor, especially prevalent in the southern regions of China. Although chemotherapy regimens based on ADM have achieved certain therapeutic effects in early treatment, the issue of ADM resistance sever...
Overexpression of RGPR-p117 reveals anticancer effects by regulating multiple signaling pathways in bone metastatic human breast cancer MDA-MB-231 cells [0.03%]
RGPR-p117过表达通过调控骨转移人乳腺癌MDA-MB-231细胞的多条信号通路发挥抗癌作用
Masayoshi Yamaguchi,Tomiyasu Murata,Noriaki Shimokawa
Masayoshi Yamaguchi
The role of RGPR-p117, a transcription factor, which binds to the TTGGC motif in the promoter region of the regucalcin gene, in cell regulation remains to be investigated. This study elucidated whether RGPR-p117 regulates the activity of tr...
Keivan Ardeshiri,Hadi Hassannia,Ghasem Ghalamfarsa et al.
Keivan Ardeshiri et al.
Targeting the influencing factors in tumor growth and expansion in the tumor microenvironment is one of the key approaches to cancer immunotherapy. Various factors in the tumor microenvironment can in cooperation stimulate tumor growth, sup...
The therapeutic effects of induced pluripotent stem cell-derived mesenchymal stem cells on Parkinson's disease [0.03%]
诱导多能干细胞来源的间充质干细胞治疗帕金森病的效果研究
Hao Ren,Yuwei Wang,Yingying Chen et al.
Hao Ren et al.
Parkinson's disease (PD), characterized by progressive degeneration of dopaminergic neurons in substantia nigra, has no disease-modifying therapy. Mesenchymal stem cell (MSC) therapy has shown great promise as a disease-modifying solution f...
Keratinocyte exosomal LOC285194 ameliorates psoriasis by inhibiting the differentiation of CD4+T cells to Th17 cells through regulating miR-211-5p/SIRT1 axis [0.03%]
角质细胞源外泌体通过调控miR-211-5p/SIRT1轴抑制CD4⁺T细胞向Th17分化从而改善银屑病
Jin Lin,Yi Cao,Lili Ma et al.
Jin Lin et al.
Keratinocytes exosome participates in the pathogenesis of psoriasis and exosomes always carry long non-coding RNAs (lncRNAs) into target cells to function as an essential immune regulator in psoriasis-related diseases. LncRNA LOC285194 is c...
Ketorolac disturbs proteasome functions and induces mitochondrial abnormality-associated apoptosis [0.03%]
ketorolac通过干扰蛋白酶体功能诱导线粒体异常相关的细胞凋亡
Prashant Kumar,Sumit Kinger,Ankur Rakesh Dubey et al.
Prashant Kumar et al.
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended to treat moderate-to-severe pain. Previous studies suggest that NSAIDs can suppress cellular proliferation and elevate apoptosis in different cancer cells. Ketorolac is an NSAID...
Ethical bioprospecting and microbial assessments for sustainable solutions to the AMR crisis [0.03%]
道德生物勘探和微生物评价在可持续解决抗微生物药物耐药性危机中的作用
Kayla Cartledge,Francesca L Short,Alex Hall et al.
Kayla Cartledge et al.
Antimicrobial resistance (AMR) has been declared one of the top 10 global public health challenges of our age by the World Health Organization, and the World Bank describes AMR as a crisis affecting the finance, health, and agriculture sect...