Euryhaline Black Yeasts From the Arabian Gulf: Descriptions of Salinomyces qatarensis sp. nov. and Hortaea werneckii Genotypic Variations [0.03%]
来自阿拉伯湾的广盐性黑酵母菌：Salinomyces qatarensis 新型种和Hortaea werneckii 代表新基因型的分类描述
Rashmi Fotedar,Polona Zalar,Amina Al Malaki et al.
Rashmi Fotedar et al.
The Arabian Gulf surrounding Qatar is an oligotrophic marine environment characterized by extreme conditions, such as increased water temperatures and high salinity compared to other semi-enclosed seas, such as the Mediterranean Sea. Thirty...
Squalene: A High-Value Compound for COVID-19 Vaccine Adjuvants and Beyond Pathways, Production Strategies, and Market Potential [0.03%]
角鲨烯：新冠疫苗佐剂的高附加值化合物及市场前景：路径、生产策略与潜力分析
Dileep Dasari,Reeta Rani Singhania,Shashi Kant Bhatia et al.
Dileep Dasari et al.
Squalene, a naturally occurring triterpene, has gained significant attention due to its critical role as an adjuvant in COVID-19 vaccines and its broad applications in pharmaceuticals, cosmetics, and nutraceuticals. This review explores the...
Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS/YARS1 Depletion [0.03%]
酪氨酸和苯丙氨酸激活神经元DNA修复，但对全局转录产生相反影响，并且成年雌性小鼠能够抵抗TyrRS / YARS1耗尽的影响
Megha Jhanji,Ashita Bhan,Colin Arrowood et al.
Megha Jhanji et al.
Serum tyrosine and phenylalanine levels increase during aging and age-associated disorders. We previously showed that tyrosyl-tRNA synthetase (TyrRS/YARS1) is reduced in Alzheimer's Disease (AD) brains, and tyrosine and phenylalanine decrea...
Emanuele Vitale,Davide Ricci,Federica Corrao et al.
Emanuele Vitale et al.
Over 7000 rare diseases have been described, collectively affecting 350 million people worldwide. Most of these conditions result from nonsense mutations, representing approximately 10% of all genetic mutations associated with human inherit...
Advancing Therapeutic Strategies for Nonsense-Related Diseases: From Small Molecules to Nucleic Acid-Based Innovations [0.03%]
nonsense相关疾病的治疗策略研究从小分子到核酸创新疗法的发展
Davide Ricci,Ilenia Cruciata,Ignazio Fiduccia et al.
Davide Ricci et al.
Nonsense mutations in gene coding regions introduce an in-frame premature termination codon (PTC) in the mRNA transcript, resulting in the early termination of translation and the production of a truncated, nonfunctional protein. The absenc...
Discovery and Validation of a New Biomarker Integrating Ferroptosis and Glycolysis-Related Genes in Bladder Cancer [0.03%]
整合铁死亡和糖酵解相关基因的新的生物标志物在膀胱癌中的发现与验证
Chenyang Wang,Yuncong Shu,Jiaqi Shan et al.
Chenyang Wang et al.
Bladder cancer (BCa) is a highly invasive tumor with few successful therapies, and its unfavorable prognosis mainly stems from late diagnosis and resistance to treatment. Ferroptosis is a type of non-apoptotic cell death characterized by ir...
Proline- and Serine-Rich Coiled-Coil 1 Predicts an Unfavorable Prognosis and Exhibits Oncogenic Activities in Breast Cancer [0.03%]
脯氨酸和丝氨酸丰富型卷曲螺旋蛋白1通过致癌作用预测乳腺癌预后不良
Xin Jin,Qingqing Zhao,Xiaowen Hao et al.
Xin Jin et al.
Proline- and serine-rich coiled-coil 1 (PSRC1) has been implicated in various cancers, yet its role in breast cancer (BRCA) remains incompletely understood. Here, we employed the UALCAN database to explore PSRC1 expression in BRCA and obtai...
Contrast-Induced Acute Kidney Injury is Modulated by Circadian CLOCK/NRF2 Pathway [0.03%]
生物钟CLOCK/NRF2通路调节造影剂引起的急性肾损伤事件
Shuqing Yang,Xinxin Xu,Lulu Wang et al.
Shuqing Yang et al.
Numerous kidney functions exhibit substantial circadian oscillations, such as renal blood flow, glomerular filtration rate, tubular reabsorption function, and erythropoietin production. The onset and the injury of acute kidney injury caused...
Hermansky-Pudlak Syndrome: From Molecular Pathogenesis to Targeted Therapies [0.03%]
赫尔曼斯基-普杜拉综合征：从分子发病机制到靶向治疗
Francesca Tondi,Roberta Annamaria Cirsmaru,Chiara Conti et al.
Francesca Tondi et al.
Hermansky-Pudlak syndrome (HPS) is a rare inherited disorder caused by defects in lysosome-related organelles (LROs) in various tissues, including platelets, melanocytes, and endothelial cells. Key features of HPS include oculocutaneous alb...
The combination of midkine inhibitor with Lenvatinib amplifies the suppression of hepatocellular carcinoma [0.03%]
.midkine抑制剂与仑伐替尼联用可增强对肝细胞癌的抑制作用
Xue Chen,Shujun Guo,Qilin Meng et al.
Xue Chen et al.
Hepatocellular carcinoma (HCC) accounts for 75%-85% of primary liver cancer cases globally. HCC patients have a poor prognosis because of tumor metastasis and medication resistance; thus, novel therapy targets and techniques are needed. By ...